Introduction Cecal ligation and puncture (CLP) is an inflammatory condition that leads to
multisystemic organ failure. Flavocoxid, a dual inhibitor of cyclooxygenase (COX-2) and 5 …

Background Administration of a selective β1-blocker, such as esmolol, in human septic
shock has demonstrated cardiovascular protective effects related to heart rate reduction …

Background Sepsis is the leading cause of death among critically ill patients, and no specific
therapeutic agent is currently approved for the treatment of sepsis. Methods We assessed …

Introduction Oxidative stress is involved in the development of secondary tissue damage
and organ failure. Micronutrients contributing to the antioxidant (AOX) defense exhibit low …

Introduction Systemic inflammation in sepsis is initiated by interactions between pathogen
molecular motifs and specific host receptors, especially toll-like receptors (TLRs). Flagellin is …

Introduction Cardiac surgery encompasses various stimuli that trigger pro-inflammatory
mediators, reactive oxygen species and mobilization of leucocytes. The aim of this study was …

Background Hepatic injury after ischemia/reperfusion is attributed to thedevelopment of
oxygen free radical (OFR)-mediated lipid peroxidation-aprocess that can be measured …

Objectives The intestinal epithelium compartmentalizes the sterile bloodstream and the
commensal bacteria in the gut. Accumulating evidence suggests that this barrier is impaired …

Introduction Stimulation of beta 2-adrenergic receptors (β 2-ARs) inhibits tumor necrosis
factor-alpha (TNF-α) release in monocytes. In septic shock, endogenous catecholamines …

Introduction Prevention of lymphocyte apoptosis by caspase inhibition has been proposed
as a novel treatment approach in sepsis. However, it has not been clearly demonstrated that …