Chondroitin sulfate (CS) is a sulfated glycosaminoglycan composed of a long chain of
repeating disaccharide units that are attached to core proteins, resulting in CS …

J. Neurochem.(2011) 119, 176–188. Abstract The formation of the glial scar following a
spinal cord injury presents a significant barrier to the regenerative process. It is primarily …

Biopolymers in the human body belong to three major classes: polynucleotides (DNA, RNA),
polypeptides (proteins) and polysaccharides (glycans). Although striking progress in our …

Chondroitin sulfate proteoglycans (CSPGs) are the main component of the extracellular
matrix in the central nervous system (CNS) and influence neuroplasticity. Although CSPG is …

The current dogma in neural regeneration research implies that chondroitin sulfate
proteoglycans (CSPGs) inhibit plasticity and regeneration in the adult central nervous …

Emerging evidence supports an increased role for NG2/CSPG4-expressing cells in the
process of neuroregeneration and synaptic plasticity, due to the increased production of …

After injury to the adult central nervous system, levels of extracellular matrix molecules
increase at the injury site and may inhibit the repair of injured axons. Among these …

Background The extracellular matrix (ECM) of the brain is rich in glycosaminoglycans such
as chondroitin sulfate (CS) and hyaluronan. These glycosaminoglycans are organized into …

The chondroitin sulfate proteoglycans (CSPGs) have been implicated as both positive and
negative modulators of axonal growth; however, the functional properties of only a few …

The extension of axons through the major inhibitory component of the glial scar, chondroitin
sulfate proteoglycans (CSPGs), remains a key obstacle for regeneration following spinal …