The brain extracellular matrix (ECM) is involved in several aspects of neuronal development,
plasticity, and pathophysiology. Chondroitin sulfate proteoglycans (CSPGs), consisting of …

Nerve tissue regeneration is a significant problem. After neural diseases and damage such
as spinal cord injury (SCI), the accumulation of chondroitin sulfate proteoglycans (CSPG) …

Chondroitin sulfate (CS) and dermatan sulfate (DS) proteoglycans (PGs) are major
extracellular matrix (ECM) components of the central nervous system (CNS). A large body of …

Like other biomolecules including nucleic acid and protein, glycan plays pivotal roles in
various cellular processes. For instance, it modulates protein folding and stability, organizes …

Axons in the peripheral nervous system can regenerate after injury, whereas axons in the
central nervous system (CNS) do not readily regenerate. Intrinsic regenerating capacity and …

Neurite outgrowth is a critical but challenging function for the regeneration of impaired
neurons. Chondroitin sulfate (CS) plays key roles in regulating cellular behaviors of …

Following brain trauma, chondroitin sulphate proteoglycans (CSPGs) are enriched at injury
sites and in denervated areas. At injury sites, CSPGs are regarded as inhibitors of axonal …

Chondroitin sulfate (CS) is an important glycosaminoglycan and is mainly found in the
extracellular matrix as CS proteoglycans. In the brain, CS proteoglycans are highly …

Chondroitin sulfate proteoglycans (CSPGs) are up‐regulated following spinal cord injury
and are partly responsible for failed regeneration. Experimental paradigms in vivo that …

The extracellular matrix of the central nervous system (CNS) serves as both a supporting
structure for cells and a rich source of signaling molecules that can influence cell …