Updates in lymph node and skin pathology of adult T-cell leukemia/lymphoma, biomarkers, and beyond

BD Adkins, JC Ramos, M Bliss-Moreau… - Seminars in diagnostic …, 2020 - Elsevier
Adult T-cell leukemia/lymphoma (ATLL) is a mature T-cell lymphoproliferative disorder
associated with the human T lymphotropic virus (HTLV-1) infection. ATLL predominantly …

Pathogenicity and virulence of human T lymphotropic virus type-1 (HTLV-1) in oncogenesis: adult T-cell leukemia/lymphoma (ATLL)

S Ahmadi Ghezeldasht, DJ Blackbourn… - Critical Reviews in …, 2023 - Taylor & Francis
Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy of CD4+ T
lymphocytes caused by human T lymphotropic virus type-1 (HTLV-1) infection. HTLV-1 was …

Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma

K Kataoka, M Iwanaga, J Yasunaga… - Blood, The Journal …, 2018 - ashpublications.org
Adult T-cell leukemia/lymphoma (ATL) is a heterogeneous group of peripheral T-cell
malignancies characterized by human T-cell leukemia virus type-1 infection, whose genetic …

Clonal evolution of adult T-cell leukemia/lymphoma takes place in the lymph nodes

A Umino, M Nakagawa, A Utsunomiya… - Blood, The Journal …, 2011 - ashpublications.org
Adult T-cell leukemia/lymphoma (ATLL) is the neoplasm caused by human T-cell leukemia
virus type 1 (HTLV-1). We performed oligo-array comparative genomic hybridization (CGH) …

North American ATLL has a distinct mutational and transcriptional profile and responds to epigenetic therapies

UA Shah, EY Chung, O Giricz… - Blood, The Journal …, 2018 - ashpublications.org
Adult T-cell leukemia lymphoma (ATLL) is a rare T cell neoplasm that is endemic in
Japanese, Caribbean, and Latin American populations. Most North American ATLL patients …

Identification of subtype-specific genomic alterations in aggressive adult T-cell leukemia/lymphoma

A Oshiro, H Tagawa, K Ohshima, K Karube, N Uike… - Blood, 2006 - ashpublications.org
Aggressive adult T-cell leukemia/lymphoma (ATLL) such as acute and lymphoma types are
fatal diseases with poor prognosis. Although these 2 subtypes feature different …

Molecular characterization of chronic-type adult T-cell leukemia/lymphoma

N Yoshida, K Karube, A Utsunomiya, K Tsukasaki… - Cancer research, 2014 - AACR
Adult T-cell leukemia/lymphoma (ATL) is a human T-cell leukemia virus type-1–induced
neoplasm with four clinical subtypes: acute, lymphoma, chronic, and smoldering. Although …

Molecular pathology of adult T-cell leukemia/lymphoma

K Ohshima - Oncology, 2015 - karger.com
Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell neoplasm of highly
pleomorphic lymphoid cells. ATLL is usually widely disseminated, and it is caused by human …

Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma

M Yamagishi, M Kubokawa, Y Kuze, A Suzuki… - Nature …, 2021 - nature.com
Subclonal genetic heterogeneity and their diverse gene expression impose serious
problems in understanding the behavior of cancers and contemplating therapeutic …

HTLV-1-related adult T-cell leukemia/lymphoma: insights in early detection and management

S Wolf, M Vercruyssen, L Cook - Current Opinion in Oncology, 2022 - journals.lww.com
There is an urgent unmet need for developing novel therapies in ATL in order to improve
survival. Recent advances in the molecular and epigenetic landscape of ATL, and the early …