Previous studies suggested that differences between the behavioral effects of cocaine and
analogs of benztropine were related to the relatively slow onset of action of the latter …

Previous studies demonstrated that analogs of benztropine (BZT) possess high affinity for
the dopamine transporter, inhibit dopamine uptake, but generally have behavioral effects …

Rationale: Previous SAR studies demonstrated that small halogen substitutions on the
diphenylether system of benztropine (BZT), such as a para-Cl group, retained high affinity at …

Previous studies demonstrated that analogs of benztropine (BZT) possess high affinity for
the dopamine (DA) transporter (DAT) but generally have behavioral effects different from …

The current studies evaluated the novel diphenylmethoxytropane analog 4-
chlorobenztropine (4-Cl-BZT), cocaine, and combinations of the two drugs for their abilities …

The benztropine analog N-(n-butyl)-3α-[bis (4′-fluorophenyl) methoxy]-tropane (JHW 007)
displays high affinity for the dopamine transporter (DAT), but unlike typical DAT ligands, has …

Benztropine (BZT) and its analogues inhibit dopamine uptake and bind with moderate to
high affinity to the dopamine transporter (DAT). However, many of these compounds, in …

An N-butyl analog of benztropine, JHW007 [N-(n-butyl)-3 α-[bis (4′-fluorophenyl) methoxy]-
tropane], binds to dopamine transporters (DAT) but has reduced cocaine-like behavioral …

Previous research has shown that phenyltropane derivatives of cocaine are very potent
ligands for dopamine transporters in in vitro binding and uptake, and in in vivo binding …

Rationale N-substituted benztropine analogs are potent dopamine uptake inhibitors that
display pharmacokinetic/dynamic properties consistent with the profile of a substitute …