Background Neuromyelitis optica (NMO), a severe demyelinating disease, represents itself
with optic neuritis and longitudinally extensive transverse myelitis. Serum NMO-IgG …

Background Neuromyelitis optica (NMO) is a demyelinating disease of the central nervous
system (CNS) of putative autoimmune aetiology. Early discrimination between multiple …

Background: Antibodies to aquaporin-4 (AQP4-Ab), known as NMO-IgG, are a sensitive and
specific marker for neuromyelitis optica (NMO). Methods: To develop an enzyme-linked …

Neuromyelitis Optica (NMO) is an autoimmune demyelinating disease, characterized by the
presence of autoantibody (NMO-IgG) to Aquaporin-4 (AQP4). NMO-IgG identification …

The current study presents a western blot assay showing good sensitivity (81%) and
specificity (97%) for detecting serum antibodies to Aquaporin-4 (AQP4) in patients with …

Neuromyelitis optica (NMO) is a severe inflammatory CNS disorder of putative autoimmune
aetiology, which predominantly affects the spinal cord and optic nerves. Recently, a highly …

Abstract Aquaporin‐4 (AQP 4) is a water channel protein that is most highly, but not
exclusively, expressed in the central nervous system. In 2005 AQP 4 was shown to be the …

Abstract Background In 70-80% of cases, neuromyelitis optica (NMO) is associated with
highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG) …

Background: Neuromyelitis optica (NMO) is a severe inflammatory demyelinating disease
that predominantly affects the optic nerve and spinal cord. Since the discovery of a specific …

Background Antibodies targeting membrane proteins play an important role in various
autoimmune diseases of the nervous system. So far, assays allowing proper analysis of …