Background: To clarify the clinical relevance of anti-aquaporin-4 (anti-AQP4) antibody titers
and immunoglobulin (IgG) subclass. Methods: Using a bridging enzyme-linked …

The detection of antibodies against aquaporin-4 (AQP4) has improved the diagnosis of
neuromyelitis optica (NMO). We evaluated a recently established cell-based anti-AQP4 …

BACKGROUND: Recently, a highly specific serum autoantibody was discovered in patients
with neuromyelitis optica, called NMO-IgG, and aquaporin-4, the most abundant water …

NMO-IgG, a disease-specific autoantibody for neuromyelitis optica, recognizes aquaporin-4
(AQP4) and has been examined by indirect immunofluorescence assay. We developed an …

Background: A new autoantibody (termed NMO-IgG, or AQP4-Ab) has recently been
described in patients with neuromyelitis optica (NMO) and its formes frustes, longitudinally …

Abstract Aquaporin-4 (AQP4) has recently been implicated in the pathogenesis of
neuromyelitis optica (NMO) where it has been identified as the first defined autoantigen …

Background Antibodies to the water channel protein aquaporin-4 (AQP4), which is
expressed in astrocytic endfeet at the blood brain barrier, have been identified in the serum …

Objectives: Traditionally, neuromyelitis optica (NMO) was known to involve only the optic
nerves and spinal cord. However, the discovery of highly specific anti-aquaporin-4 (AQP4) …

Neuromyelitis optica (NMO) is an inflammatory disease affecting the optic nerve and spinal
cord, in which autoantibodies against aquaporin 4 (AQP4) water channel protein probably …

Antibodies to aquaporin‐4 (called NMO‐IgG or AQP4‐Ab) constitute a sensitive and highly
specific serum marker of neuromyelitis optica (NMO) that can facilitate the differential …