Outcome of severe congenital hypothyroidism: closing the developmental gap with early high dose levothyroxine treatment

JM Dubuis, J Glorieux, F Richer, CL Deal… - The Journal of …, 1996 - academic.oup.com
We have previously reported that despite neonatal screening, children with severe
congenital hypothyroidism treated at 5 weeks of age with 6 micrograms/kg. day …

Congenital hypothyroidism clinical aspects and late consequences.

A Büyükgebiz - Pediatric endocrinology reviews: PER, 2003 - europepmc.org
Congenital hypothyroidism (CH) is the commonest treatable cause of mental retardation.
The prevelance is 1/3000-1/4000 live births worldwide. The importance of CH is that, the …

Results of the screening program for congenital hypothyroidism in Berlin (1978–1995)

A Grüters, KP Liesenkötter, M Zapico… - Experimental and …, 1997 - thieme-connect.com
Screening for congenital hypothyroidism for all newborns of the former western parts of the
city of Berlin was instituted in 1978 by determination of the TSH levels in dried filter paper …

Prepubertal and pubertal growth, timing and duration of puberty and attained adult height in patients with congenital hypothyroidism (CH) detected by the neonatal …

Z Dickerman, L De Vries - Clinical Endocrinology, 1997 - Wiley Online Library
OBJECTIVE We have evaluated parameters of growth, the pubertal process and attained
adult height in patients with congenital hypothyroidism (CH) of various aetiologies …

[HTML][HTML] Linear growth and neurodevelopmental outcome of children with congenital hypothyroidism detected by neonatal screening: A controlled study

AT Soliman, S Azzam, A ElAwwa… - Indian journal of …, 2012 - journals.lww.com
Materials and Methods: We studied the longitudinal growth pattern and assessed the
neurodevelopment of 45 children with CH (25 girls, 20 boys) diagnosed through the national …

Neurological abnormalities in patients treated for hypothyroidism from early life.

R Macfaul, S Dorner, EM Brett, DB Grant - Archives of Disease in …, 1978 - adc.bmj.com
Neurological and psycholocial assessment was carried out on 30 patients aged 2.7 to 21
years (mean 9.4) who were being treated for hypothyroidism starting before the age of 2 …

Evaluation and management of the child with hypothyroidism

AKC Leung, AAC Leung - World Journal of Pediatrics, 2019 - Springer
Background Thyroid hormones are critical for early neurocognitive development as well as
growth and development throughout childhood. Prompt recognition and treatment of …

Neurodevelopmental and body composition outcomes in children with congenital hypothyroidism treated with high-dose initial replacement and close monitoring

BB Albert, N Heather, JGB Derraik… - The Journal of …, 2013 - academic.oup.com
Background: Despite newborn screening and early levothyroxine replacement, there are
continued reports of mild neurocognitive impairment in children with congenital …

Endocrinology and adolescence: congenital hypothyroidism: a clinical update of long-term outcome in young adults

J Léger - European journal of endocrinology, 2015 - academic.oup.com
Congenital hypothyroidism (CH) is the most common congenital endocrine disorder. The
early treatment of CH patients has successfully improved the prognosis and management of …

[HTML][HTML] Congenital hypothyroidism: insights into pathogenesis and treatment

CE Cherella, AJ Wassner - International journal of pediatric endocrinology, 2017 - Springer
Congenital hypothyroidism occurs in approximately 1 in 2000 newborns and can have
devastating neurodevelopmental consequences if not detected and treated promptly. While …