Endothelium-dependent relaxations cannot be fully explained by the release of either NO
or/and prostacyclin. Another unidentified substance (s) which hyperpolarizes the underlying …

Institut de Recherches Internationale Servier, 6 Place des Pleides, 92415 Courbevoie,
Cedex, FranceINTRODUCTIONEndothelial cells synthesise and release vasoactive …

The endothelial cells inhibit the tone of the underlying vascular smooth muscle by releasing
endothelium-derived relaxing factors (EDRF). The existence of at least two such factors …

Endothelium‐derived hyperpolarization (EDH) has been reported in many vessels and an
extensive literature suggests that a novel, non‐nitric oxide and non‐prostanoid, endothelium …

1. Endothelium‐derived relaxing factor is almost universally considered to be synonymous
with nitric oxide (NO); however, it is now well established that at least two other chemically …

Endothelial-dependent relaxation of vascular smooth muscle cells evoked by a number of
agonists, including cholinomimetics and substance P, is often accompanied by an increase …

The endothelium controls vascular tone not only by releasing nitric oxide (NO) and
prostacyclin but also by other pathways causing hyperpolarization of the underlying smooth …

Although nitric oxide appears to be the major endothelium-derived relaxing factor (EDRF), it
cannot explain all endothelium-dependent responses of isolated arteries. Thus …

The endothelium maintains vascular homeostasis through the release of active vasodilators.
Although nitric oxide (NO) is recognized as the primary factor at level of conduit arteries …

Endothelial cells control the tone and the growth of the underlying vascular smooth muscle
by releasing Nitric Oxide (NO). This introduction summarizes the early experiments which …