The human ion channel TRPM2 modulates neuroblastoma cell survival and mitochondrial function through Pyk2, CREB, and MCU activation
I Hirschler-Laszkiewicz, S Chen… - … of Physiology-Cell …, 2018 - journals.physiology.org
Transient receptor potential melastatin channel subfamily member 2 (TRPM2) has an
essential function in cell survival and is highly expressed in many cancers. Inhibition of …
essential function in cell survival and is highly expressed in many cancers. Inhibition of …
Depletion of the human ion channel TRPM2 in neuroblastoma demonstrates its key role in cell survival through modulation of mitochondrial reactive oxygen species …
L Bao, S Chen, K Conrad, K Keefer, T Abraham… - Journal of Biological …, 2016 - ASBMB
Transient receptor potential melastatin 2 (TRPM2) ion channel has an essential function in
modulating cell survival following oxidant injury and is highly expressed in many cancers …
modulating cell survival following oxidant injury and is highly expressed in many cancers …
The human ion channel TRPM2 modulates cell survival in neuroblastoma through E2F1 and FOXM1
I Hirschler-Laszkiewicz, F Festa, S Huang… - Scientific reports, 2022 - nature.com
Transient receptor potential channel melastatin 2 (TRPM2) is highly expressed in cancer
and has an essential function in preserving viability through maintenance of mitochondrial …
and has an essential function in preserving viability through maintenance of mitochondrial …
A splice variant of the human ion channel TRPM2 modulates neuroblastoma tumor growth through hypoxia-inducible factor (HIF)-1/2α
S Chen, NE Hoffman, S Shanmughapriya, L Bao… - Journal of Biological …, 2014 - ASBMB
The calcium-permeable ion channel TRPM2 is highly expressed in a number of cancers. In
neuroblastoma, full-length TRPM2 (TRPM2-L) protected cells from moderate oxidative stress …
neuroblastoma, full-length TRPM2 (TRPM2-L) protected cells from moderate oxidative stress …
Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy
S Chen, L Bao, K Keefer, S Shanmughapriya… - Cell death & …, 2020 - nature.com
Transient receptor potential melastatin 2 (TRPM2) ion channel has an essential function in
maintaining cell survival following oxidant injury. Here, we show that TRPM2 is highly …
maintaining cell survival following oxidant injury. Here, we show that TRPM2 is highly …
TRPM2 in Cancer
BA Miller - Cell Calcium, 2019 - Elsevier
The TRP ion channel TRPM2 has an essential function in cell survival and protects the
viability of a number of cell types after oxidative stress. It is highly expressed in many …
viability of a number of cell types after oxidative stress. It is highly expressed in many …
Role of TRPM2 in cell proliferation and susceptibility to oxidative stress
S Chen, W Zhang, Q Tong, K Conrad… - … of Physiology-Cell …, 2013 - journals.physiology.org
The transient receptor potential (TRP) channel TRPM2 is an ion channel that modulates cell
survival. We report here that full-length (TRPM2-L) and short (TRPM2-S) isoform expression …
survival. We report here that full-length (TRPM2-L) and short (TRPM2-S) isoform expression …
TRPM2-mediated Ca2+ signaling as a potential therapeutic target in cancer treatment: an updated review of its role in survival and proliferation of cancer cells
ES Ali, B Chakrabarty, S Ramproshad… - Cell Communication and …, 2023 - Springer
The transient receptor potential melastatin subfamily member 2 (TRPM2), a thermo and
reactive oxygen species (ROS) sensitive Ca2+-permeable cation channel has a vital role in …
reactive oxygen species (ROS) sensitive Ca2+-permeable cation channel has a vital role in …
Role of TRPM2 in brain tumours and potential as a drug target
D Ji, Z Luo, A Ovcjak, R Alanazi, MH Bao… - Acta Pharmacologica …, 2022 - nature.com
Ion channels are ubiquitously expressed in almost all living cells, and are the third-largest
category of drug targets, following enzymes and receptors. The transient receptor potential …
category of drug targets, following enzymes and receptors. The transient receptor potential …
[HTML][HTML] TRPM8 is required for survival and radioresistance of glioblastoma cells
D Klumpp, SC Frank, L Klumpp, EC Sezgin, M Eckert… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract TRPM8 is a Ca 2+-permeable nonselective cation channel belonging to the
melastatin sub-group of the transient receptor potential (TRP) family. TRPM8 is aberrantly …
melastatin sub-group of the transient receptor potential (TRP) family. TRPM8 is aberrantly …