2022 Canadian Cardiovascular Society guideline for use of GLP-1 receptor agonists and SGLT2 inhibitors for cardiorenal risk reduction in adults

GBJ Mancini, E O'Meara, S Zieroth, M Bernier… - Canadian Journal of …, 2022 - Elsevier
This guideline synthesizes clinical trial data supporting the role of glucagon-like peptide-1
receptor agonists and sodium-glucose co-transporter 2 inhibitors (SGLT2i) for treatment of …

Glucagon-like peptide-1 receptor agonists in type 2 diabetes: a meta-analysis of randomized clinical trials

M Monami, N Marchionni… - European journal of …, 2009 - academic.oup.com
Objective The role of glucagon-like peptide-1 (GLP-1) receptor agonists in the treatment of
type 2 diabetes is debated; many recent trials, which were not included in previous meta …

[HTML][HTML] Worldwide inertia to the use of cardiorenal protective glucose-lowering drugs (SGLT2i and GLP-1 RA) in high-risk patients with type 2 diabetes

G Schernthaner, N Shehadeh, AS Ametov… - Cardiovascular …, 2020 - Springer
The disclosure of proven cardiorenal benefits with certain antidiabetic agents was supposed
to herald a new era in the management of type 2 diabetes (T2D), especially for the many …

[HTML][HTML] GLP-1 analogs and DPP-4 inhibitors in type 2 diabetes therapy: review of head-to-head clinical trials

MP Gilbert, RE Pratley - Frontiers in endocrinology, 2020 - frontiersin.org
The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent
insulinotropic polypeptide (GIP) are released from enteroendocrine cells in response to the …

[HTML][HTML] Metabolic and cardiovascular benefits of GLP‑1 agonists, besides the hypoglycemic effect

RA Iorga, N Bacalbasa, M Carsote… - Experimental and …, 2020 - spandidos-publications.com
Patients with type 2 diabetes exhibit higher cardiovascular risk than normal individuals.
Optimal blood glucose levels are rarely achieved in diabetic patients. Glucagon‑like peptide …

Glucagon-like peptide-1 receptor agonists: a class update for treating type 2 diabetes

JA Lovshin - Canadian journal of diabetes, 2017 - Elsevier
Current management options for treating type 2 diabetes are diverse. Many different classes
of antidiabetes therapies are used in clinic, and several new candidates are in late-phase …

Cardiovascular and renal outcomes with efpeglenatide in type 2 diabetes

HC Gerstein, N Sattar, J Rosenstock… - New England journal …, 2021 - Mass Medical Soc
Background Four glucagon-like peptide-1 (GLP-1) receptor agonists that are structurally
similar to human GLP-1 have been shown to reduce the risk of adverse cardiovascular …

Dulaglutide and renal outcomes in type 2 diabetes: an exploratory analysis of the REWIND randomised, placebo-controlled trial

HC Gerstein, HM Colhoun, GR Dagenais, R Diaz… - The Lancet, 2019 - thelancet.com
Background Two glucagon-like peptide-1 (GLP-1) receptor agonists reduced renal
outcomes in people with type 2 diabetes at risk for cardiovascular disease. We assessed the …

Safety and tolerability of once‐weekly GLP‐1 receptor agonists in type 2 diabetes

J Trujillo - Journal of clinical pharmacy and therapeutics, 2020 - Wiley Online Library
What is known and objective In recent years, glucagon‐like peptide‐1 receptor agonists
(GLP‐1 RAs) including once‐weekly (QW) formulations have been incorporated into type 2 …