Chemerin-induced arterial contraction is Gi-and calcium-dependent
DJ Ferland, ES Darios, RR Neubig, B Sjögren… - Vascular …, 2017 - Elsevier
Chemerin is an adipokine associated with increased blood pressure, and may link obesity
with hypertension. We tested the hypothesis that chemerin-induced contraction of the …
with hypertension. We tested the hypothesis that chemerin-induced contraction of the …
Chemerin connects fat to arterial contraction
SW Watts, AM Dorrance, ME Penfold… - … , and vascular biology, 2013 - Am Heart Assoc
Objective—Obesity and hypertension are comorbid in epidemic proportion, yet their
biological connection is largely a mystery. The peptide chemerin is a candidate for …
biological connection is largely a mystery. The peptide chemerin is a candidate for …
Chemerin reduces vascular nitric oxide/cGMP signalling in rat aorta: a link to vascular dysfunction in obesity?
The adipokine chemerin has been implicated in cardiovascular complications associated
with obesity and the metabolic syndrome. Chemerin has direct effects on the vasculature …
with obesity and the metabolic syndrome. Chemerin has direct effects on the vasculature …
Chemerin promotes the proliferation and migration of vascular smooth muscle and increases mouse blood pressure
H Kunimoto, K Kazama, M Takai… - American Journal …, 2015 - journals.physiology.org
Blood chemerin concentration shows positive correlation not only with body mass index and
serum triglyceride level but also with systolic blood pressure. While it seems likely that …
serum triglyceride level but also with systolic blood pressure. While it seems likely that …
Chemerin is resident to vascular tunicas and contributes to vascular tone
E Wabel, A Orr, ED Flood… - American Journal …, 2023 - journals.physiology.org
The adipokine chemerin may support blood pressure, evidenced by a fall in mean arterial
pressure after whole body antisense oligonucleotide (ASO)-mediated knockdown of …
pressure after whole body antisense oligonucleotide (ASO)-mediated knockdown of …
Role of chemerin in cardiovascular diseases
(1) Background: Obesity is closely connected to the pathophysiology of cardiovascular
diseases (CVDs). Excess fat accumulation is associated with metabolic malfunctions that …
diseases (CVDs). Excess fat accumulation is associated with metabolic malfunctions that …
Chemerin regulates crosstalk between adipocytes and vascular cells through Nox
Adipocytes produce adipokines, including chemerin, a chemoattractant that mediates effects
through its ChemR23 receptor. Chemerin has been linked to endothelial dysfunction and …
through its ChemR23 receptor. Chemerin has been linked to endothelial dysfunction and …
Chemerin: a comprehensive review elucidating the need for cardiovascular research
DJ Ferland, SW Watts - Pharmacological research, 2015 - Elsevier
When chemerin was discovered in 1997, it was relegated to being a protein associated with
the normal skin function contrasting the setting of psoriasis. However, with the discovery of …
the normal skin function contrasting the setting of psoriasis. However, with the discovery of …
Chemerin Elicits Potent Constrictor Actions via Chemokine‐Like Receptor 1 (CMKLR 1), not G‐Protein‐Coupled Receptor 1 (GPR 1), in Human and Rat Vasculature
AJ Kennedy, P Yang, C Read, RE Kuc… - Journal of the …, 2016 - Am Heart Assoc
Background Circulating levels of chemerin are significantly higher in hypertensive patients
and positively correlate with blood pressure. Chemerin activates chemokine‐like receptor 1 …
and positively correlate with blood pressure. Chemerin activates chemokine‐like receptor 1 …
Chemerin as a driver of hypertension: a consideration
DJ Ferland, AE Mullick, SW Watts - American journal of …, 2020 - academic.oup.com
The protein chemerin (tazarotene-induced gene, TIG2; RARRES2) is a relatively new
adipokine. Many studies support that circulating chemerin levels associate strongly and …
adipokine. Many studies support that circulating chemerin levels associate strongly and …