Neural tube closure has been studied for many decades, across a range of vertebrates, as a
paradigm of embryonic morphogenesis. Neurulation is of particular interest in view of the …

Neurulation is a morphogenetic event par excellence. During this highly choreographed four-
dimensional process, a flat sheet of ectoderm is transformed into an elongated tubular …

Neurulation, the process of neural tube formation, is a complex morphogenetic event. In the
mammalian embryo, an understanding of the dynamic nature of neurulation has been …

The development of the embryonic brain critically depends on successfully completing
cranial neural tube closure (NTC). Failure to properly close the neural tube results in …

Neural tube closure is a fundamental embryonic event whose molecular regulation is poorly
understood. As mouse neurulation progresses along the spinal axis, there is a shift from …

The developmental process of neurulation involves a series of coordinated morphological
events, which result in conversion of the flat neural plate into the neural tube, the primordium …

Neural tube defects arise from mechanical failures in the process of neurulation. At the most
fundamental level, formation of the neural tube relies on coordinated, complex tissue …

During early development of the central nervous system, the neuroepithelial cells undergo
dynamic changes in shape, cumulative action of which cause the neural plate to bend …

Planar-cell-polarity (PCP) signalling is necessary for initiation of neural tube closure in
higher vertebrates. In mice with PCP gene mutations, a broad embryonic midline prevents …

Neural tube closure is a critical developmental event that relies on actomyosin contractility to
facilitate specific processes such as apical constriction, tissue bending, and directional cell …