Continuously perfused microbubble array for 3D tumor spheroid model
S Agastin, UBT Giang, Y Geng, LA DeLouise… - …, 2011 - pubs.aip.org
Multi-cellular tumor spheroids (MCTSs) have been established as a 3D physiologically
relevant tumor model for drug testing in cancer research. However, it is difficult to control the …
relevant tumor model for drug testing in cancer research. However, it is difficult to control the …
Multidimensional controllable fabrication of tumor spheroids based on a microfluidic device
Y Hou, Y Zheng, X Zheng, Y Sun, X Yi, Z Wu, JM Lin - Lab on a Chip, 2023 - pubs.rsc.org
Multicellular tumor spheroids (MCTSs) are in vitro solid tumor models with physiological
relevance. To achieve robust process control, a MCTS fabrication method that combines cell …
relevance. To achieve robust process control, a MCTS fabrication method that combines cell …
Drug testing and flow cytometry analysis on a large number of uniform sized tumor spheroids using a microfluidic device
Abstract Three-dimensional (3D) tumor spheroid possesses great potential as an in vitro
model to improve predictive capacity for pre-clinical drug testing. In this paper, we combine …
model to improve predictive capacity for pre-clinical drug testing. In this paper, we combine …
Mass fabrication of uniform sized 3D tumor spheroid using high-throughput microfluidic system
In vivo tumors develop in a three-dimensional manner and have unique and complex
characteristics. Physico-biochemical barriers on tumors cause drug resistance and limit drug …
characteristics. Physico-biochemical barriers on tumors cause drug resistance and limit drug …
3D multicellular tumor spheroids in a microfluidic droplet system for investigation of drug resistance
A three-dimensional (3D) tumor spheroid model plays a critical role in mimicking tumor
microenvironments in vivo. However, the conventional culture methods lack the ability to …
microenvironments in vivo. However, the conventional culture methods lack the ability to …
Gradient-sized control of tumor spheroids on a single chip
Multicellular tumor spheroids are attracting more attention as a physiologically relevant in
vitro tumor model for biomedical research. The size of spheroids is one of the critical …
vitro tumor model for biomedical research. The size of spheroids is one of the critical …
[HTML][HTML] High-throughput microfluidics for evaluating microbubble enhanced delivery of cancer therapeutics in spheroid cultures
Drug penetration into solid tumours remains a major challenge in the effective treatment of
cancer. Microbubble (MB) mediated sonoporation offers a potential solution to this by …
cancer. Microbubble (MB) mediated sonoporation offers a potential solution to this by …
A novel three-dimensional microfluidic platform for on chip multicellular tumor spheroid formation and culture
The formation of three-dimensional (3D) multicellular cell spheroids such as microspheres
and embryoid bodies has recently gained much attention as a useful cell culture technique …
and embryoid bodies has recently gained much attention as a useful cell culture technique …
Drug cytotoxicity and signaling pathway analysis with three-dimensional tumor spheroids in a microwell-based microfluidic chip for drug screening
Y Chen, D Gao, H Liu, S Lin, Y Jiang - Analytica chimica acta, 2015 - Elsevier
Currently, there has been a growing need for developing in vitro models to better reflect
organism response to chemotherapy at tissue level. For this reason, a microfluidic platform …
organism response to chemotherapy at tissue level. For this reason, a microfluidic platform …
Transitioning from multi-phase to single-phase microfluidics for long-term culture and treatment of multicellular spheroids
When compared to methodologies based on low adhesion or hanging drop plates, droplet
microfluidics offers several advantages for the formation and culture of multicellular …
microfluidics offers several advantages for the formation and culture of multicellular …