The kit ligand, stem cell factor
SJ Galli, KM Zsebo, EN Geissler - Advances in immunology, 1993 - Elsevier
Publisher Summary This chapter focuses on the importance of stem cell factor (SCF) and the
stem cell factor receptor (SCFR) in hematopoiesis and other complex developmental …
stem cell factor receptor (SCFR) in hematopoiesis and other complex developmental …
The c-kit receptor, stem cell factor, and mast cells. What each is teaching us about the others.
Many years ago, alert observers noticed among thousands of laboratory mice a few
individuals that, unlike their littermates, exhibited areas of white spotting on their fur. No one …
individuals that, unlike their littermates, exhibited areas of white spotting on their fur. No one …
The biology of stem cell factor and its receptor C-kit
LK Ashman - The international journal of biochemistry & cell biology, 1999 - Elsevier
The receptor tyrosine kinase c-Kit and its ligand Stem Cell Factor (SCF) are essential for
haemopoiesis, melanogenesis and fertility. SCF acts at multiple levels of the haemopoietic …
haemopoiesis, melanogenesis and fertility. SCF acts at multiple levels of the haemopoietic …
Regulation of Mouse and Human Mast Cell Development, Survival and Function by Stem Cell Factor, the Ligand for the c-kit Receptor
Stem cell factor (SCF), the ligand for the receptor (SCFR) that is encoded by the c-kit proto-
oncogene, has many important effects in mouse and human mast cell development, survival …
oncogene, has many important effects in mouse and human mast cell development, survival …
Stem cell factor and hematopoiesis
VC Broudy - Blood, The Journal of the American Society of …, 1997 - ashpublications.org
Stem cell factor (SCF; also known as kit ligand, mast cell ultimate destinations during
development. Hematopoietic cells growth factor, or steel factor) is a hematopoietic cytokine …
development. Hematopoietic cells growth factor, or steel factor) is a hematopoietic cytokine …
Murine cutaneous mastocytosis and epidermal melanocytosis induced by keratinocyte expression of transgenic stem cell factor
T Kunisada, SZ Lu, H Yoshida, S Nishikawa… - The Journal of …, 1998 - rupress.org
The growth and differentiation of mast cells and melanocytes require stem cell factor (SCF),
the ligand for the kit receptor tyrosine kinase. SCF may exist as a membrane-bound or …
the ligand for the kit receptor tyrosine kinase. SCF may exist as a membrane-bound or …
KIT as a master regulator of the mast cell lineage
The discovery in 1987/1988 and 1990 of the cell surface receptor KIT and its ligand, stem
cell factor (SCF), was a critical achievement in efforts to understand the development and …
cell factor (SCF), was a critical achievement in efforts to understand the development and …
Interspecies molecular chimeras of kit help define the binding site of the stem cell factor
S Lev, J Blechman, SI Nishikawa, D Givol… - Molecular and cellular …, 1993 - Taylor & Francis
The extracellular portion of the kit-encoded receptor for the stem cell factor (SCF) comprises
five immunoglobulin (Ig)-like domains. To localize the ligand recognition site, we exploited …
five immunoglobulin (Ig)-like domains. To localize the ligand recognition site, we exploited …
The c-kit ligand, stem cell factor, promotes mast cell survival by suppressing apoptosis.
A Iemura, M Tsai, A Ando, BK Wershil… - The American journal of …, 1994 - ncbi.nlm.nih.gov
Stem cell factor (SCF) and its receptor (SCFR), a member of the receptor tyrosine kinase III
family that is encoded by the c-kit gene, critically regulate several complex biological …
family that is encoded by the c-kit gene, critically regulate several complex biological …
Recombinant human stem cell factor, a c-kit ligand, stimulates hematopoiesis in primates
RG Andrews, GH Knitter, SH Bartelmez, KE Langley… - 1991 - ashpublications.org
Recombinant human stem cell factor (SCF) is homologous with recombinant rat SCF (rrSCF)
and is a ligand for c-kit. We determined the influence of SCF on hematopoiesis in vitro and in …
and is a ligand for c-kit. We determined the influence of SCF on hematopoiesis in vitro and in …