Intellectual disability (ID) can be caused by non-genetic and genetic factors, the latter being
responsible for more than 1700 ID-related disorders. The broad ID phenotypic and genetic …

To identify candidate genes for intellectual disability, we performed a meta-analysis on
2,637 de novo mutations, identified from the exomes of 2,104 patient–parent trios. Statistical …

Despite the remarkable number of scientific breakthroughs of the last 100 years, the
treatment of neurodevelopmental disorders (eg, autism spectrum disorder, intellectual …

Genetic or genomic mutation is a major cause of intellectual disability (ID). However, despite
the generally anticipated strong genotype/phenotype correlation for ID, there are huge …

Background Intellectual disability (ID) is a common neurodevelopmental disorder affecting 1–
3% of the general population. Mutations in more than 10% of all human genes are …

Genetics is believed to have an important role in intellectual disability (ID). Recent studies
have emphasized the involvement of de novo mutations (DNMs) in ID but the extent to which …

Intellectual disability (ID) disorders are genetically and phenotypically extremely
heterogeneous. Can this complexity be depicted in a comprehensive way as a means of …

The genetics of autosomal recessive intellectual disability (ARID) has mainly been studied in
consanguineous families, however, founder populations may also be of interest to study …

Intellectual disability affects about 3% of individuals globally, with∼ 50% idiopathic. We
designed an exonic-resolution array targeting all known submicroscopic chromosomal …

The identification of causes underlying intellectual disability (ID) is one of the most
demanding challenges for clinical Geneticists and Researchers. Despite molecular …