Heterotrimeric guanine nucleotide-binding proteins are composed of alpha and beta gamma
subunits and couple a variety of cell-surface receptors to intracellular enzymes or ion …

G proteins are active as long as GTP is bound to the alpha subunit. Activation ends when
GTP is cleaved to GDP that then stays bound to the active site. Agonist-liganded receptors …

The reversible association of alpha and beta gamma subunits of GTP-binding proteins is
important for signal transmission from a variety of cell-surface receptors to intracellular …

The heterotrimeric G proteins are often regarded functionally as a heterodimer, consisting of
a guanine nucleotide-binding alpha subunit and a beta gamma subunit complex. Since the …

The guanine nucleotide binding proteins (G proteins) that couple hormone and other
receptors to a variety of intracellular effector enzymes and ion channels are heterotrimers of …

Several GTP binding proteins, including EF-Tu, Ypt1, rab-5, and FtsY, and adenylosuccinate
synthetase have been reported to bind xanthine nucleotides when the conserved aspartate …

Revised Manuscript Received January 30, 1995® abstract: Receptors activate the Ga
subunits of heterotrimeric G proteins by binding tothe C-terminus and reducing their affinity …

Multiple heterotrimeric guanine nucleotide binding protein (G protein) subunits have evolved
to couple a large variety of receptors to intracellular effectors. G protein beta gamma …

G protein-mediated signal transduction is dependent on alpha subunit interactions with beta
gamma subunits, receptors, effectors, magnesium ions, and guanine nucleotides. The …

Nucleotide binding properties of the G protein alpha subunit G (o) alpha were probed by
mutational analysis in recombinant Escherichia coli. Thousands of random mutations …