[HTML] plos.org

[HTML][HTML] Epigenetic control of viral life-cycle by a DNA-methylation dependent transcription factor

K Flower, D Thomas, J Heather, S Ramasubramanyan… - PloS one, 2011 - journals.plos.org
Epstein-Barr virus (EBV) encoded transcription factor Zta (BZLF1, ZEBRA, EB1) is the
prototype of a class of transcription factor (including C/EBPalpha) that interact with CpG …
被引用次数：57 相关文章 所有 13 个版本
[HTML] frontiersin.org

[HTML][HTML] Epigenetic control of Epstein–Barr virus transcription–relevance to viral life cycle?

AJ Sinclair - Frontiers in Genetics, 2013 - frontiersin.org
DNA methylation normally leads to silencing of gene expression but Epstein–Barr virus
(EBV) provides an exception to the epigenetic paradigm. DNA methylation is absolutely …
被引用次数：28 相关文章 所有 11 个版本
[HTML] plos.org

[HTML][HTML] CpG-methylation regulates a class of Epstein-Barr virus promoters

M Bergbauer, M Kalla, A Schmeinck, C Göbel… - PLoS …, 2010 - journals.plos.org
DNA methylation is the major modification of eukaryotic genomes and plays an essential
role in mammalian gene regulation. In general, cytosine-phosphatidyl-guanosine (CpG) …
被引用次数：136 相关文章 所有 16 个版本
[HTML] oup.comFull View

Structural basis of DNA methylation-dependent site selectivity of the Epstein–Barr virus lytic switch protein ZEBRA/Zta/BZLF1

F Bernaudat, M Gustems, J Günther… - Nucleic acids …, 2022 - academic.oup.com
Abstract In infected cells, Epstein–Barr virus (EBV) alternates between latency and lytic
replication. The viral bZIP transcription factor ZEBRA (Zta, BZLF1) regulates this cycle by …
被引用次数：9 相关文章 所有 11 个版本
[PDF] researchgate.net

The reversal of epigenetic silencing of the EBV genome is regulated by viral bZIP protein

QH Karlsson, C Schelcher, E Verrall, C Petosa… - 2008 - portlandpress.com
EBV (Epstein–Barr virus) alternates between latency and lytic replication. During latency, the
viral genome is largely silenced by host-driven methylation of CpG motifs and in the switch …
被引用次数：23 相关文章 所有 7 个版本
[HTML] plos.org

[HTML][HTML] BZLF1 governs CpG-methylated chromatin of Epstein-Barr Virus reversing epigenetic repression

A Woellmer, JM Arteaga-Salas, W Hammerschmidt - 2012 - journals.plos.org
Epigenetic mechanisms are essential for the regulation of all genes in mammalian cells but
transcriptional repression including DNA methylation are also major epigenetic mechanisms …
被引用次数：103 相关文章 所有 14 个版本
[PDF] asm.orgFull View

Genome-wide analyses of Zta binding to the Epstein-Barr virus genome reveals interactions in both early and late lytic cycles and an epigenetic switch leading to an …

S Ramasubramanyan, A Kanhere, K Osborn… - Journal of …, 2012 - Am Soc Microbiol
ABSTRACT The Epstein-Barr virus (EBV) genome sustains substantial epigenetic
modification involving chromatin remodelling and DNA methylation during lytic replication …
被引用次数：42 相关文章 所有 12 个版本
[HTML] nih.gov

Epstein–Barr virus and host cell methylation: regulation of latency, replication and virus reactivation

A Woellmer, W Hammerschmidt - Current opinion in virology, 2013 - Elsevier
Highlights•EBV's life cycle consists of a prelatent, a latent, and a lytic phase.•Each phase is
characterized by a unique set of active and silenced viral genes.•Cell-driven epigenetic …
被引用次数：94 相关文章 所有 6 个版本
[HTML] plos.org

[HTML][HTML] Methylation-dependent binding of the epstein-barr virus BZLF1 protein to viral promoters

SJ Dickerson, Y Xing, AR Robinson, WT Seaman… - PLoS …, 2009 - journals.plos.org
The switch between latent and lytic Epstein-Barr virus (EBV) infection is mediated by the
viral immediate-early (IE) protein, BZLF1 (Z). Z, a homologue of c-jun that binds to AP1-like …
被引用次数：100 相关文章 所有 18 个版本

The EBV lytic switch protein, Z, preferentially binds to and activates the methylated viral genome

PM Bhende, WT Seaman, HJ Delecluse, SC Kenney - Nature genetics, 2004 - nature.com
DNA methylation promotes gene silencing, yet the Epstein-Barr virus immediate-early
protein, BZLF1 (Z), converts the virus from the latent to the lytic form of infection even when …
被引用次数：262 相关文章 所有 10 个版本