Dynamic chromatin environment of key lytic cycle regulatory regions of the Epstein-Barr virus genome

S Ramasubramanyan, K Osborn, K Flower… - Journal of …, 2012 - Am Soc Microbiol
ABSTRACT The ability of Epstein-Barr virus (EBV) to establish latency allows it to evade the
immune system and to persist for the lifetime of its host; one distinguishing characteristic is …

5-hydroxymethylation of the EBV genome regulates the latent to lytic switch

CK Wille, DM Nawandar, AN Henning… - Proceedings of the …, 2015 - National Acad Sciences
Latent Epstein–Barr virus (EBV) infection and cellular hypermethylation are hallmarks of
undifferentiated nasopharyngeal carcinoma (NPC). However, EBV infection of normal oral …

Epigenetics of Epstein Barr virus—A review

G Shareena, D Kumar - Biochimica et Biophysica Acta (BBA)-Molecular …, 2023 - Elsevier
Epstein Barr is the first-in-human oncogenic virus, closely related to numerous
lymphoproliferative and malignant diseases, including HL, BL, NPC, and GC. EBV …

Methylation of the EBV genome and establishment of restricted latency in low-passage EBV-infected 293 epithelial cells

EJ Paulson, JD Fingeroth, JL Yates, SH Speck - Virology, 2002 - Elsevier
Epstein–Barr virus (EBV) encodes multiple latency programs: a growth-transforming
program (type III) latency program and restricted-latency (types I and II) programs. During …

Differential methylation of Epstein-Barr virus latency promoters facilitates viral persistence in healthy seropositive individuals

EJ Paulson, SH Speck - Journal of virology, 1999 - Am Soc Microbiol
Epstein-Barr virus (EBV) establishes a life-long infection in humans, with distinct viral latency
programs predominating during acute and chronic phases of infection. Only a subset of the …

Interaction sites of the Epstein–Barr virus Zta transcription factor with the host genome in epithelial cells

A Godfrey, K Osborn, AJ Sinclair - Access Microbiology, 2021 - microbiologyresearch.org
Epstein–Barr virus (EBV) is present in a state of latency in infected memory B-cells and EBV-
associated lymphoid and epithelial cancers. Cell stimulation or differentiation of infected B …

Regulation of Epstein–Barr virus reactivation from latency

T Murata - Microbiology and immunology, 2014 - Wiley Online Library
Abstract The Epstein–Barr virus (EBV) is a human gamma‐herpesvirus that is implicated in
various types of proliferative diseases. Upon infection, it predominantly establishes latency …

[HTML][HTML] Asymmetric Arginine dimethylation of Epstein–Barr virus nuclear antigen 2 promotes DNA targeting

H Gross, S Barth, RD Palermo, A Mamiani, C Hennard… - Virology, 2010 - Elsevier
The Epstein–Barr virus (EBV) growth-transforms B-lymphocytes. The virus-encoded nuclear
antigen 2 (EBNA2) is essential for transformation and activates gene expression by …

In vitro transcriptional activation, dimerization, and DNA-binding specificity of the Epstein-Barr virus Zta protein

PM Lieberman, AJ Berk - Journal of virology, 1990 - Am Soc Microbiol
The Epstein-Barr virus BZLF1 immediate-early gene encodes a transcriptional activator
protein, Zta, which acts as a key regulatory switch in the transition between the latent and …

Mapping promoter regions that are hypersensitive to methylation-mediated inhibition of transcription: application of the methylation cassette assay to the Epstein-Barr …

KD Robertson, RF Ambinder - Journal of virology, 1997 - Am Soc Microbiol
Methylation-associated transcriptional repression is recognized in many settings and may
play a role in normal differentiation and in tumorigenesis. Both sequence-specific and …