I. Introduction............................................................................................. 447 II. Disrupted
homeostasis as a shared toxicological mechanismin many disease states …

During the evolution of single-celled organisms to multicellular metazoans, a family of highly
conserved genes coding for proteins (connexins), which as hexameric units (connexons) …

Communication mechanisms [extra-, intra-, and gap junctional inter-cellular communication
(GJIC)] control, from the fertilized egg, through embryogenesis to maturity and aging …

The normal development and health of all multicellular organisms, including the human
being, depend on the adaptive maintenance of the integrity of the genetic information (eg …

Gap junctional intercellular communication (GJIC) plays a central role in coordinating signal‐
transduction pathways that control gene expression inside of cells with those of neighboring …

The incidence of brain pathologies has increased during last decades. Better diagnosis
(autism spectrum disorders) and longer life expectancy (Parkinson's disease, Alzheimer's …

The mechanistic relationship of the inhibition of gap junctional intercellular communication
(GJIC) to other toxicological phenomena was explored using a recently developed method …

Gap junctions were initially defined by their morphology in transmission electron
micrographs, where they appear as very close appositions of membranes of adjacent cells …

In spite of the early speculation by Loewenstein that one of the critical distinguishing
phenotypes of cancers from normal cells was the dysfunction of gap junctional intercellular …

The presence of pesticides in drinking water poses a human health risk and disinfection can
either exacerbate or reduce these health risks by producing by-products that are either more …