Studies conducted in rodents subjected to chronic stress and some observations in humans
after psychosocial stress, have allowed to establish a link between stress and the …

Previous research has demonstrated that the behaviors observed in chronic unpredictable
mild stressed (CUMS) rats are similar to the symptoms of depressed patients and that the …

Depression is a chronic debilitating disorder predicted to affect around 20% of the world
population. Both brain and peripheral changes, including neuroplastic changes have been …

Early-life stress is a main contributory factor to the onset of depression. Treatments remain
inadequate and as such, a large unmet medical need for novel therapeutics remains …

Stress plays a major role in inducing depression, which may arise from interplay between
complex cascades of molecular and cellular events that influence gene expression leading …

Depression is a debilitating psychiatric disorder with a high rate of relapse and a low rate of
response to antidepressant treatment. There is a dearth of new antidepressants due to an …

Abstract Background Nucleus Accumbens (NAc) is a vital brain region for the process of
reward and stress, whereas microRNA plays a crucial role in depression pathology …

The amygdala is a brain structure considered a key node for the regulation of
neuroendocrine stress response. Stress-induced response in amygdala is accomplished …

Contrary to intuition, most individuals are resilient to psychological trauma and only a
minority is vulnerable. Men and women are known to respond differently to trauma …

MicroRNAs (miRNAs) may contribute to the development of depression and its treatment.
Here, we used the hypothesis-neutral approach of next-generation sequencing (NGS) to …