Hyaluronic acid-grafted bioprosthetic heart valves achieved by copolymerization exhibited improved anticalcification and antithrombogenicity

X Huang, C Zheng, K Ding, M Li, S Zhang… - ACS Biomaterials …, 2022 - ACS Publications
Bioprosthetic heart valves (BHVs) are widely used in clinic, but they still have problems of
calcification, thrombogenicity, and cytotoxicity. The reported techniques based on …

Dual-crosslinked bioprosthetic heart valves prepared by glutaraldehyde crosslinked pericardium and poly-2-hydroxyethyl methacrylate exhibited improved …

X Huang, C Zheng, K Ding, S Zhang, Y Lei, Q Wei… - Acta Biomaterialia, 2022 - Elsevier
Bioprosthetic heart valves (BHVs) have been widely used due to the revolutionary
transcatheter aortic valve replacement (TAVR) techniques but suffer from a limited lifespan …

Poly (2-methoxyethyl acrylate) coated bioprosthetic heart valves by copolymerization with enhanced anticoagulant, anti-inflammatory, and anti-calcification properties

X Liang, Y Lei, K Ding, X Huang, C Zheng… - Journal of Materials …, 2022 - pubs.rsc.org
Commercial glutaraldehyde (Glut) cross-linked bioprosthetic heart valves (BHVs) fabricated
from the pericardium have become the most popular choice for treating heart valve …

Cross-linking porcine pericardium by 3, 4-dihydroxybenzaldehyde: a novel method to improve the biocompatibility of bioprosthetic valve

B Wu, C Zheng, K Ding, X Huang, M Li… - …, 2020 - ACS Publications
Heart valve replacement is an effective therapy for patients with moderate to severe valvular
stenosis or regurgitation. Most bioprosthetic heart valves applied clinically are based on …

Exogenous hyaluronic acid and chondroitin sulfate crosslinking treatment for increasing the amount and stability of glycosaminoglycans in bioprosthetic heart valves

Y Lei, Q Ning, Y Tang, Y Wang - Journal of Materials Science: Materials in …, 2019 - Springer
Glutaraldehyde (GLUT) crosslinked bioprosthetic heart valves (BHVs) might fail due to
progressive degradation and calcification. GLUT cannot stabilize glycosaminoglycans …

A functionalized biological heart valve by double bond crosslinking with enhanced biocompatibility and antithrombogenicity

C Zheng, D Kuang, K Ding, X Huang, H Fan… - Journal of Materials …, 2022 - pubs.rsc.org
With the advancement of minimally invasive interventional therapy, biological heart valves
(BHVs) have been extensively used in clinics. However, BHVs are generally prone to …

Epoxy chitosan-crosslinked acellular bovine pericardium with improved anti-calcification and biological properties

Z Sun, J Liu, X Wang, H Jing, B Li, D Kong… - ACS Applied Bio …, 2020 - ACS Publications
Glutaraldehyde (GA) was conventionally used to crosslink bovine pericardium to prepare
bioprosthetic heart valves (BHVs), which usually fail within 10 years because of valve …

A PEGylation method of fabricating bioprosthetic heart valves based on glutaraldehyde and 2-amino-4-pentenoic acid co-crosslinking with improved …

K Ding, C Zheng, X Huang, S Zhang, M Li, Y Lei… - Acta Biomaterialia, 2022 - Elsevier
With the development of diagnostic techniques, the incidence of bioprosthetic heart valve
thrombosis (BHVT) is found to be seriously underestimated. Developing bioprosthetic heart …

[HTML][HTML] A bioprosthetic heart valve prepared by copolymerization of 2-isocyanatoethyl methacrylate modified pericardium and functional monomer

C Zheng, K Ding, X Huang, L Yang, Y Lei… - Composites Part B …, 2022 - Elsevier
Bioprosthetic heart valves (BHVs), mostly fabricated from glutaraldehyde crosslinked
porcine or bovine pericardium, have been increasingly used in clinic with the application of …

[HTML][HTML] Double bond crosslinked and phosphocholinated biological heart valve with robust antithrombogenicity, durability and anticalcification property

C Zheng, X Huang, K Ding, D Kuang, L Yang… - Composites Part B …, 2023 - Elsevier
Glutaraldehyde crosslinked biological heart valves (BHVs) are increasingly implanted with
development of transcatheter heart valve implantation. While poor cytocompatibility and …