Neurodegenerative diseases comprise a wide spectrum of pathologies characterized by
progressive loss of neuronal functions and structures. Despite having different genetic …

As the population ages, the incidence of neurodegenerative diseases is increasing. Due to
intensive research, important steps in the elucidation of pathogenetic cascades have been …

The distinguishing pathogenic features of neurodegenerative diseases include
mitochondrial dysfunction and derived reactive oxygen species generation. The neural …

In recent years, multiple disciplines have focused on mitochondrial biology and contributed
to understanding its relevance towards adult-onset neurodegenerative disorders. These are …

Oxidative stress is a metabolic condition arising from imbalance between the production of
potentially reactive oxygen species and the scavenging activities. Mitochondria are the main …

A growing body of evidence suggests the alteration of the reduction-oxidation (redox)
homeostasis in the brain grown with the increasing of the age. The brain is composed of …

Mitochondrial dysfunction and oxidative stress are two interdependent and reinforcing
damage mechanisms that play a central role in brain aging. Oxidative stress initiated and …

Aging is a physiologic state in which a progressive decline of organ functions may be
accompanied by developing age-related diseases and neurodegenerative diseases. The …

Age is the main risk factor for a number of human diseases, including neurodegenerative
disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral …

Age-related dementias such as Alzheimer disease (AD) have been linked to vascular
disorders like hypertension, diabetes and atherosclerosis. These risk factors cause …