Background Factors involved in the regulation of muscle mass in chronic obstructive
pulmonary disease (COPD) are still poorly understood. Comparing the signalisation …

Chronic obstructive pulmonary disease (COPD) is a worldwide prevalent respiratory disease
mainly caused by tobacco smoke exposure. COPD is now considered as a systemic disease …

COPD is a debilitating disease impacting negatively on health status and the functional
capacity of patients. COPD goes beyond the lungs and incurs significant systemic effects …

We investigated whether atrophy and hypertrophy signalling were altered in the diaphragm
of chronic obstructive pulmonary disease (COPD) patients. We studied diaphragm fibre …

Epigenetic events are differentially expressed in the lungs and airways of patients with
chronic obstructive pulmonary disease (COPD). Moreover, epigenetic mechanisms are …

Disease exacerbations and muscle wasting comprise negative prognostic factors of chronic
obstructive pulmonary disease (COPD). Transient systemic inflammation and malnutrition …

Epigenetic mechanisms regulate muscle mass and function in models of muscle dysfunction
and atrophy. We assessed whether quadriceps muscle weakness and atrophy are …

Peripheral muscle wasting is a common finding in advanced chronic obstructive pulmonary
disease (COPD) and several other chronic diseases. Although muscle wasting has long …

Skeletal muscle wasting contributes to impaired exercise capacity, reduced health-related
quality of life and is an independent determinant of mortality in chronic obstructive …

COPD (chronic obstructive pulmonary disease), although primarily a disease of the lungs,
exhibits secondary systemic manifestations. The skeletal muscles are of particular interest …