Skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease
negatively impacts quality of life and survival. Cigarette smoking (CS) is the major risk factor …

Background Fibrosis is defined as an excessive accumulation of extracellular matrix (ECM)
components. Many organs are subjected to fibrosis including the lung, liver, heart, skin …

Low exercise tolerance has a large influence on health status in chronic obstructive
pulmonary disease and chronic heart failure. In addition to primary organ dysfunction …

The skeletal muscles play an essential role in life, providing the mechanical basis for
respiration and movement. Skeletal muscle dysfunction is prevalent in all stages of chronic …

Background: Although the loss of peripheral muscle mass has been shown convincingly in
chronic obstructive pulmonary disease (COPD), the underlying pathogenesis remains …

Key points Chronic obstructive pulmonary disease (COPD) is largely caused by smoking,
and patient limb muscle exhibits a fast fibre shift and atrophy. We show that this fast fibre …

A profound remodeling of the diaphragm and vastus lateralis (VL) occurs in patients with
moderate-to-severe chronic obstructive pulmonary disease (COPD). In this mini-review, we …

Loss of skeletal muscle mass is now recognised as an important feature of chronic
obstructive pulmonary disease (COPD) which contributes to symptoms and influences …

Background Skeletal muscle depletion is an important complication of chronic obstructive
pulmonary disease (COPD) but little prospective data exists about the rate at which it occurs …

Background: Systemic proinflammatory cytokines and oxidative stress have been described
in association with peripheral muscle wasting and weakness of patients with severe chronic …