Design, Synthesis of Novel Tetrandrine-14-l-Amino Acid and Tetrandrine-14-l-Amino Acid-Urea Derivatives as Potential Anti-Cancer Agents

SC Hu, J Yang, C Chen, JR Song, WD Pan - Molecules, 2020 - mdpi.com
Tetrandrine, a dibenzyltetrahydroisoquinoline alkaloid isolated from the root of the traditional
Chinese medicinal plant Stephania tetrandra S. Moore, a member of the Menispermaceae …

Design and synthesis of novel C14-urea-tetrandrine derivatives with potent anti-cancer activity

J Lan, L Huang, H Lou, C Chen, T Liu, S Hu… - European journal of …, 2018 - Elsevier
Tetrandrine is a dibenzyltetrahydroisoquinoline alkaloid, isolated from traditional Chinese
medicinal plant Stephania tetrandra, with anti-tumor activity. Our previous study identified …

Design, synthesis and in vitro anticancer research of novel tetrandrine and fangchinoline derivatives

X Gao, X Lv, R Zhang, Y Luo, M Wang, J Chen… - Bioorganic …, 2021 - Elsevier
Cancer treatment is one of the major public health issues in the world. Tetrandrine (Tet) and
fangchinoline (d-Tet) are two bis-benzyl isoquinoline alkaloids extracted from Stephania …

Design and synthesis of novel tetrandrine derivatives as potential anti-tumor agents against human hepatocellular carcinoma

J Lan, N Wang, L Huang, Y Liu, X Ma, H Lou… - European journal of …, 2017 - Elsevier
Tetrandrine, a lead anti-tumor compound with a bis-benzyltetrahydroisoquinoline skeleton
isolated from medicinal plant Stephania tetrandra. In order to obtain active anti-tumor agents …

Synthesis and antitumor activity of tetrandrine derivatives

CZ Wu, L Lai, X Hu, RR Lei, YF Yang - Journal of Asian natural …, 2013 - Taylor & Francis
Tetrandrine possesses antitumor activity, however, only a few studies on its structure
modification were reported. To improve the antitumor activity of tetrandrine, 20 new …

Design, synthesis and bioactivity investigation of tetrandrine derivatives as potential anti-cancer agents

J Song, J Lan, C Chen, S Hu, J Song, W Liu, X Zeng… - …, 2018 - pubs.rsc.org
Twenty-four 14-sulfonamide–tetrandrine derivatives as potential anti-cancer agents were
synthesized. The synthetic derivatives were investigated for their cytotoxic activity against …

Design and synthesis of new tetrandrine derivatives and their antitumor activities

X Wei, TL Qu, YF Yang, JF Xu, XW Li… - Journal of asian …, 2016 - Taylor & Francis
A series of tetrandrine derivatives were designed and synthesized using Suzuki coupling
reaction. Eleven targeted compounds with over 50% inhibition against HL60 and A549 …

Synthesis of 5-alkynyltetrandrine derivatives and evaluation of their anticancer activity on A549 cell lines

N Niu, T Qu, J Xu, X Lu, GJ Bodwell… - Anti-Cancer Agents in …, 2019 - ingentaconnect.com
Background: Lung cancer is one of the most prevalent malignancies and thus the
development of novel therapeutic agents for managing lung cancer is imperative …

Synthesis of novel tetrandrine derivatives and their inhibition against NSCLC A549 cells

QH Yang, CS Jiang, T Jin, JF Xu, TL Qu… - Journal of Asian …, 2018 - Taylor & Francis
A series of novel tetrandrine (Tet) derivatives were synthesized through Suzuki-Miyaura
reaction and evaluated for their cytotoxicity against human non-small cell lung carcinoma …

Design, synthesis, and biological evaluation of N14-amino acid-substituted tetrandrine derivatives as potential antitumor agents against human colorectal cancer

YC Wang, RH Zhang, SC Hu, H Zhang, D Yang… - Molecules, 2022 - mdpi.com
As a typical dibenzylisoquinoline alkaloid, tetrandrine (TET) is clinically used for the
treatment of silicosis, inflammatory pulmonary, and cardiovascular diseases in China …