Prolonged elevation of intraocular pressure results in retinal ganglion cell loss and abnormal retinal function in mice

AK Khan, YT Dennis, ME Van Der Heijden… - Experimental eye …, 2015 - Elsevier
The purpose of this study was to assess the impact of prolonged intraocular pressure (IOP)
elevation on retinal anatomy and function in a mouse model of experimental glaucoma. IOP …

Angiotensin II related glial cell activation and necroptosis of retinal ganglion cells after systemic hypotension in glaucoma

SJ Jeon, J Huh, E Jeong, CK Park, HYL Park - Cell Death & Disease, 2022 - nature.com
The purpose of this study was to design an animal model mimicking glaucoma with
hemodynamic instability and to identify involvement of angiotensin II (AngII) and associated …

Neuroprotection in glaucoma

ER Tamm, F Grehn, N Pfeiffer - Cell and tissue research, 2013 - Springer
Glaucoma is a frequent eye disease in the elderly and the second leading cause of
irreversible blindness both in developed and developing countries (Resnikoff et al. 2004) …

Experimental model of ocular hypertension in the rat: study of the optic nerve capillaries and action of hypotensive drugs

F Díaz, A Villena, L Vidal, M Moreno… - … & visual science, 2010 - iovs.arvojournals.org
Purpose.: To investigate quantitatively the effect of elevated intraocular pressure (IOP) on
the microvasculature of the optic nerve with and without topical treatment with two …

The effect of increased pressure on in vitro survival of transfected rat retinal ganglion cells

KV Chalam, WW Phillips, V Shah… - … & Visual Science, 2004 - iovs.arvojournals.org
Purpose: To study the effect of varying pressure on the survival of retinal ganglion cells
(RGC) at differential time intervals in a closed chamber pressure system. Methods: Rat …

Protective effect of erigeron breviscapus (Vant.) hand-mazz on retinal ganglion cells and optic nerve in rabbits with elevated intraocular pressure

Z Yi-sheng, X Min-hong, YE Wen - Journal of Shanghai …, 2006 - wprim.whocc.org.cn
Objective To observe the protective effect of Erigeron Breviscapus (Vant.) Hand-Mazz
(EBHM) on retinal ganglion cells (RGCs) and optic nerve in rabbits with elevated intraocular …

The dark phase intraocular pressure elevation and retinal ganglion cell degeneration in a rat model of experimental glaucoma

JMK Kwong, N Vo, A Quan, M Nam, H Kyung… - Experimental eye …, 2013 - Elsevier
Intraocular pressure (IOP) elevation is considered as a major risk factor causing the
progression of vision deterioration in glaucoma. Although it is known that the IOP level …

Retinal ganglion cell death in a DBA/2J mouse model of glaucoma: Microglial activation and intraocular pressure

L Yang, X Guo, L Wu, Y Li, L Wu… - Neural Regeneration …, 2010 - pure.johnshopkins.edu
BACKGROUND: Retinal microglia has been shown to reactivate in a murine model of
pigmentary glaucoma. However, the relationship between microglial activation and …

Risk factors for retinal ganglion cell distress in glaucoma and neuroprotective potential intervention

S Vernazza, F Oddone, S Tirendi, AM Bassi - International Journal of …, 2021 - mdpi.com
Retinal ganglion cells (RGCs) are a population of neurons of the central nervous system
(CNS) extending with their soma to the inner retina and with their axons to the optic nerve …

Correlation between the reduced circulating endothelial progenitor cell counts and elevated intraocular pressure-induced retinal ganglion cell apoptosis

B Yao, Q Zhao, H Yan, F Chen, L Liu - Current Eye Research, 2015 - Taylor & Francis
Purpose: To investigate the correlations between intraocular pressure (IOP) and circulating
endothelial progenitor cells (EPCs), retinal ganglion cells (RGC) apoptosis and EPCs, and …