Apoptosis in skeletal myocytes: a potential target for interventions against sarcopenia and physical frailty–a mini-review
Background: Sarcopenia, the age-related loss of muscle mass and function, represents a
relevant public health issue due to its high prevalence and detrimental consequences. While …
relevant public health issue due to its high prevalence and detrimental consequences. While …
Multiple pathways to the same end: mechanisms of myonuclear apoptosis in sarcopenia of aging
E Marzetti, G Privitera, V Simili… - The Scientific World …, 2010 - Wiley Online Library
Sarcopenia, the age‐related decline in muscle mass and function, represents a significant
health issue due to the high prevalence of frailty and disability associated with this condition …
health issue due to the high prevalence of frailty and disability associated with this condition …
Skeletal muscle apoptosis, sarcopenia and frailty at old age
E Marzetti, C Leeuwenburgh - Experimental gerontology, 2006 - Elsevier
The loss of muscle mass and strength with aging, also referred to as sarcopenia of aging, is
a highly prevalent condition among older adults and predicts several adverse outcomes …
a highly prevalent condition among older adults and predicts several adverse outcomes …
Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle
Aging is inevitably associated with a progressive loss of muscle mass and strength, a
condition also known as sarcopenia of aging. Although the precise mechanisms underlying …
condition also known as sarcopenia of aging. Although the precise mechanisms underlying …
Role of apoptosis in sarcopenia
C Leeuwenburgh - The Journals of Gerontology Series A …, 2003 - academic.oup.com
Skeletal muscle atrophy and the loss of myofibers contribute to sarcopenia, a condition
associated with normal aging. However, relatively little is known regarding the relevance of …
associated with normal aging. However, relatively little is known regarding the relevance of …
The role of apoptosis in age-related skeletal muscle atrophy
AJ Dirks, C Leeuwenburgh - Sports Medicine, 2005 - Springer
Skeletal myocyte atrophy and death contribute to sarcopenia, a condition associated with
normal aging. By 80 years of age, it is estimated that humans generally lose 30–40% of …
normal aging. By 80 years of age, it is estimated that humans generally lose 30–40% of …
Apoptosis in muscle atrophy: relevance to sarcopenia
EE Dupont-Versteegden - Experimental gerontology, 2005 - Elsevier
The loss of muscle mass with aging, or sarcopenia, is an important contributor to the
functional decline and loss of independence observed with aging. Little is known about the …
functional decline and loss of independence observed with aging. Little is known about the …
Mitochondria initiate and regulate sarcopenia
SE Alway, JS Mohamed, MJ Myers - Exercise and sport sciences …, 2017 - journals.lww.com
Sarcopenia is associated with increased levels of apoptosis (47) and reduced capabilities
for muscle regeneration (41) leading to muscle wasting. For this reason, many studies …
for muscle regeneration (41) leading to muscle wasting. For this reason, many studies …
Apoptosis in skeletal muscle with aging
A Dirks, C Leeuwenburgh - American Journal of Physiology …, 2002 - journals.physiology.org
Sarcopenia may be partly due to a loss in total fiber number by apoptosis. We have
investigated age-related alterations in the mitochondria-mediated pathway leading to …
investigated age-related alterations in the mitochondria-mediated pathway leading to …
Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials
Sarcopenia, the age-related loss of muscle mass and function, imposes a dramatic burden
on individuals and society. The development of preventive and therapeutic strategies …
on individuals and society. The development of preventive and therapeutic strategies …