Evaluation of possible consequences of Zika virus infection in the developing nervous system

LT Walter, GSV Higa, JM Ikebara, D Vedovello… - Molecular …, 2018 - Springer
The Zika virus (ZIKV) outbreak that occurred in the northeast of Brazil in 2015 led to alarming
numbers of babies born with microcephaly in this region. Since then, several studies have …

Zika virus potentiates the development of neurological defects and microcephaly: Challenges and control strategies

R Siddique, Y Liu, G Nabi, W Sajjad, M Xue… - Frontiers in …, 2019 - frontiersin.org
Since the beginning of the Zika Virus (ZIKV) epidemic, thousands of cases presenting ZIKV
symptoms were recorded in Brazil, Colombia (South America), French Polynesia and other …

Potential mechanisms of Zika‐linked microcephaly

E Merfeld, L Ben‐Avi, M Kennon… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
A recent outbreak of Zika virus (ZIKV) in Brazil is associated with microcephaly in infants
born of infected mothers. As this pandemic spreads, rapid scientific investigation is shedding …

Zika virus infection histories in brain development

BLM Marcelino, BL Dos Santos… - Disease Models & …, 2023 - journals.biologists.com
An outbreak of births of microcephalic patients in Brazil motivated multiple studies on this
incident. The data left no doubt that infection by Zika virus (ZIKV) was the cause, and that this …

Infectivity of immature neurons to Zika virus: a link to congenital Zika syndrome

BW Hughes, KC Addanki, AN Sriskanda, E McLean… - …, 2016 - thelancet.com
Background Epidemiological data strongly suggest that microcephaly cases in Brazil are
associated with the ongoing epidemic of Zika virus (ZIKV). In order to further solidify the …

The impact of Zika virus in the brain

FB Russo, PCB Beltrão-Braga - Biochemical and biophysical research …, 2017 - Elsevier
The recent outbreak of ZIKV in Brazil called the attention of the world because the effects of
viral infection in the brain under development in fetuses. Consequences of vertical infection …

Zika infection and the development of neurological defects

FB Russo, P Jungmann… - Cellular …, 2017 - Wiley Online Library
Starting with the outbreak in Brazil, Zika virus (ZIKV) infection has been correlated with
severe syndromes such as congenital Zika syndrome and Guillain‐Barré syndrome. Here …

Can we better understand how Zika leads to microcephaly? A systematic review of the effects of the Zika virus on human brain organoids

B Sutarjono - The Journal of infectious diseases, 2019 - academic.oup.com
Background The innovative human brain organoid model represents a unique opportunity to
better understand the genesis of congenital brain abnormalities, particularly microcephaly …

ZIKV strains differentially affect survival of human fetal astrocytes versus neurons and traffic of ZIKV-laden endocytotic compartments

J Jorgačevski, M Korva, M Potokar, M Lisjak… - Scientific reports, 2019 - nature.com
Malformations of the fetal CNS, known as microcephaly, have been linked to Zika virus
(ZIKV) infection. Here, the responses of mammalian and mosquito cell lines, in addition to …

Zika virus infection in the developing mouse produces dramatically different neuropathology dependent on viral strain

KK Noguchi, BS Swiney, SL Williams… - Journal of …, 2020 - Soc Neuroscience
Zika virus (ZIKV) infection during pregnancy has been causally linked to a constellation of
neurodevelopmental deformities in the fetus resulting in a disease termed congenital Zika …