The formamidopyrimidine-DNA glycosylase (Fpg) recognizes and eliminates efficiently 8-
oxoguanine, an abundant mutagenic DNA lesion. The X-ray structure of the inactive E3Q …

Formamidopyrimidine‐DNA glycosylase (Fpg) identifies and removes 8‐oxoguanine from
DNA. All of the X‐ray structures of Fpg complexed to an abasic site containing DNA exhibit a …

Abstract Background Formamidopyrimidine-DNA glycosylase (Fpg) removes abundant pre-
mutagenic 8-oxoguanine (oxoG) bases from DNA through nucleophilic attack of its N …

Formamidopyrimidine-DNA glycosylase (Fpg) is a primary participant in the repair of 8-
oxoguanine, an abundant oxidative DNA lesion. Although the structure of Fpg has been …

8-Oxoguanine (8OG) is the most prevalent form of oxidative DNA damage. In bacteria, 8OG
is excised by formamidopyrimidine glycosylase (Fpg) as the initial step in base excision …

Reactive oxygen species are byproducts of normal aerobic respiration and ionizing
radiation, and they readily react with DNA to form a number of base lesions, including the …

Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidized
purines such as 7, 8-dihydro-8-oxoguanine (8-oxoG) and 2, 6-diamino-4-hydroxy-5 …

As part of an overall effort to map the energetic landscape of the base excision repair
pathway, we report the first thermodynamic characterization of repair enzyme binding to …

DNA glycosylases, the enzymes that initiate base excision DNA repair, recognize damaged
bases through a series of precisely orchestrated movements. Most glycosylases sharply kink …

Cellular DNA is constantly exposed to oxidative stress from both exogenous and
endogenous sources, creating lesions that lead to aging related diseases, including cancer …