Although cancers have altered glucose metabolism, termed the Warburg effect, which
describes the increased uptake and conversion of glucose to lactate by cancer cells under …

The MYC oncogene, which is frequently deregulated in human cancers, encodes a master
transcription factor c-Myc (herein termed Myc) that integrates cell proliferation with …

MYC is a multifunctional transcription factor that is deregulated in many human cancers.
MYC impacts a collaborative genetic program that orchestrates cell proliferation …

Abstract c-MYC and the hypoxia-inducible factors (HIFs) are critical factors for tumorigenesis
in a large number of human cancers. While the normal function of MYC involves the …

Cancer cells must rewire cellular metabolism to satisfy the demands of unbridled growth and
proliferation. As such, most human cancers differ from normal counterpart tissues by a …

Studies from many laboratories document that the MYC oncogene produces a pleiotropic
transcription factor, Myc, which influences genes driven by all three RNA polymerases to …

The ability of cancer cells to overproduce lactic acid aerobically was recognized by Warburg
about seven decades ago, although its molecular basis has been elusive. Increases in …

The MYC proto-oncogene is frequently activated in human cancers through a variety of
mechanisms. Its deregulated expression, unconstrained by inactivation of key checkpoints …

The MYC proto-oncogene is frequently deregulated in human cancers, activating genetic
programs that orchestrate biological processes to promote growth and proliferation. Altered …

The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its
precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC …