Human papillomaviruses have adjusted their replication levels to the differentiation state of
the infected keratinocyte. PV genomes replicate in undifferentiated cells at low levels and to …

Papillomavirus genomes are thought to be amplified to about 100 copies per cell soon after
infection, maintained constant at this level in basal cells, and amplified for viral production …

Human papillomaviruses (HPVs) are an ancient and highly successful group of viruses that
have co-evolved with their host to replicate in specific anatomical niches of the stratified …

Highlights•Latent papillomavirus infection can be mediated via at least two
routes.•Resolution of disease by the immune system results in basal cell persistence.•Low …

Human papillomaviruses (HPVs) target the stratified epidermis, and can causes diseases
ranging from benign condylomas to malignant tumors. Infections of HPVs in the genital tract …

Most human papillomaviruses cause inapparent infections, subtly affecting epithelial
homeostasis, to ensure genome persistence in the epithelial basal layer. As with …

We have shown that E1 and E2 proteins of human papillomavirus type 11 (HPV-11) were
essential to support the replication of the homologous viral origin (ori) in a transient …

The human papillomavirus (HPV) E6 and E7 oncogenes have direct effects on host cell
proliferation. The viral E2 protein regulates transcription of E6 and E7 and thereby has an …

Papillomaviruses have evolved a life cycle that is perfectly coordinated with the
differentiation process of the host epidermal tissue. The stratified epithelium of the …

A small group of human papillomaviruses (HPVs) cause almost all cervical carcinoma and a
significant percentage of other anogenital tract and oral carcinoma. Another group of HPVs …