Persistent infection with high-risk human papillomaviruses (HR-HPVs) is the causal factor in
over 99% of cervical cancer cases, and a significant proportion of oropharyngeal and …

HPVs (human papillomaviruses) infect epithelial cells and their replication cycle is intimately
linked to epithelial differentiation. There are over 200 different HPV genotypes identified to …

Animal and human papillomaviruses (HPVs) replicate persistently in specific types of
stratified epithelia of their host. After the initial infection, the viral genome replicates at low …

The function of the E5 protein of human papillomaviruses (HPV) is not well characterized,
and controversies exist about its role in the viral life cycle. To determine the function of E5 …

The papillomavirus E1 and E2 proteins are both necessary and sufficient in vivo for efficient
origin-dependent viral DNA replication. The ability of E1 and E2 to complex with each other …

Human papillomaviruses (HPV) are the causative agents of cervical cancer and are also
associated with other genital malignancies, as well as an increasing number of head and …

The E2 gene products of papillomavirus play key roles in viral replication, both as regulators
of viral transcription and as auxiliary factors that act with E1 in viral DNA replication. We …

Human papillomavirus (HPV) infections play a crucial role in the pathogenesis of cervical
neoplasia. Insights into the mechanisms by which HPV infection can, in a small numbers of …

Papillomaviruses possess small DNA genomes that encode five early (E) proteins. Transient
DNA replication requires activities of the E1 and E2 proteins and a DNA segment containing …

Human Papillomavirus (HPV) research has been dominated by the study of a subset of
Alpha papillomaviruses that together cause almost 5% of human cancers worldwide, with …