The papillomavirus E1 and E2 proteins are essential for viral genome replication. E1 is a
helicase that unwinds the viral origin and recruits host cellular factors to replicate the viral …

Human papillomavirus (HPV) E2 proteins regulate viral replication by binding to sites in the
upstream regulatory region (URR) and by complex formation with the E1 origin recognition …

The aetiology of cervical cancer has been primarily attributed to human papillomaviruses
(HPVs). These are characterized by the persistent expression of the two oncogenes, E6 and …

Human papillomaviruses (HPVs) from the high-risk group are associated with
cervicalcancer, in contrast to HPVs from the low-risk group which are associated with …

Numerous clinical, epidemiological and molecular findings link some types of Human
Papillomaviruses (HPV) with cancer of the genital tract. They share a common pathway of …

Human papillomaviruses (HPVs) are a family of small double-stranded DNA viruses that
have a tropism for the epithelia of the genital and upper respiratory tracts and for the skin …

DNA replication of papillomaviruses requires the viral E1 and E2 proteins. These proteins
bind cooperatively to the viral origin of replication (ori), which contains binding sites for both …

The activation of transcription and of DNA replication are, in some cases, mediated by the
same proteins. A prime example is the E2 protein of human papillomaviruses (HPVs), which …

The human papillomavirus (HPV) E7 protein is one of only two viral proteins that remain
expressed in HPV-associated human cancers. HPV E7 proteins share structural and …

Human papillomaviruses (HPVs) are the causative agents of 5% of all human cancers, with
cervical cancer being the most important. Two viral oncoproteins, E6 and E7, are essential …