Carcinogenic progression of a human papillomavirus (HPV)-infected cell is often associated
with integration of the viral genome in a manner which results in the loss of expression of the …

With the exception of viral proteins E1 and E2, papillomaviruses depend heavily on host
replication machinery for replication of their viral genome. E1 and E2 are known to recruit …

The E6 and E7 oncoproteins of the high-risk human papillomavirus (HPV) types are able to
immortalize human keratinocytes in vitro and likely contribute to the development of …

Papillomaviruses are small DNA viruses that are associated with benign and malignant
epithelial lesions, including> 95% of cervical cancers and≈ 20% of head and neck cancers …

The oncogenic potential of papillomaviruses (PVs) has been appreciated since the 1930s
yet the mechanisms of virally-mediated cellular transformation are still being revealed …

The human papillomavirus (HPV) E2 protein is an important regulator of viral E6 and E7
gene expression. E2 can repress the viral promoter for E6 and E7 expression as well as …

A hallmark of human papillomavirus (HPV) associated carcinogenesis is the integration of
the viral DNA into the cellular genome, usually accompanied by the loss of expression of the …

The papillomavirus E2 gene product plays a pivotal role in viral replication. E2 has multiple
functions, including (i) transcriptional activation and repression of viral promoters and (ii) the …

Human papillomaviruses (HPVs) comprise a diverse group, and have different epithelial
tropisms and life-cycle strategies. Many HPVs are classified as low-risk, as they are only …

E7 is an accessory protein that is not encoded by all papillomaviruses. The E7 amino
terminus contains two regions of similarity to conserved regions 1 and 2 of the adenovirus …