After two decades of clinical trials, gene therapy demonstrated effectiveness in the treatment
of a series of diseases. Currently, several gene therapy products are approved and used in …

To develop an efficient biological production process using the baculovirus–insect cell
system, recombinant protein production was investigated in an immobilized cell culture with …

The insect cell-baculovirus expression system is primarily used to express recombinant
proteins at small scale. The system has not been adopted for large scale production …

We have developed new packaging cell lines (293SF-PacLV) that can produce lentiviral
vectors (LVs) in serum-free suspension cultures. A cell line derived from 293SF cells …

Yellow fever (YF) is a life‐threatening viral disease endemic in parts of Africa and Latin
America. Although there is a very efficacious vaccine since the 1930s, YF still causes 29,000 …

The production of recombinant proteins for biotherapeutic use is a multibillion dollar
industry, which has seen continual growth in recent years. In order to produce the best …

Viral transduction of eukaryotic cell lines is one possibility to efficiently generate
recombinant proteins, and among all viral-based expression systems the baculovirus/insect …

An experimental study was undertaken to evaluate alternative insect cell lines to Sf9 [from
Spodoptera frugiperda (fall armyworm)] for the production of recombinant proteins. Insect …

Insect cell culture is recognized as an emerging technology for the production of biologicals,
including recombinant proteins and biological insecticides, primarily through the use of …

The cell density effect is a well-established constraint in the baculovirus–insect cell
expression platform, in which cell-specific productivity declines with increasing cell density …