Fine particulate matter promotes airway inflammation and mucin production by activating endoplasmic reticulum stress and the IRE1α/NOD1/NF‑κB pathway

L Hu, C Xu, X Tang, S Yu… - International …, 2023 - spandidos-publications.com
Abstract Fine particulate matter (PM2. 5) is a type of small particle that is< 2.5 µm in diameter
that may cause airway inflammation. Thus, the present study aimed to explore the effects of …

Subacute exposure of PM2. 5 induces airway inflammation through inflammatory cell infiltration and cytokine expression in rats

Y Li, B Sun, Y Shi, J Jiang, Z Du, R Chen, J Duan… - Chemosphere, 2020 - Elsevier
Accumulating evidences support that exposure to fine particulate matter (PM 2.5) could
cause inflammation of the airway, but its underlying mechanisms are less known. Our study …

Epidermal growth factor receptor (EGFR)—MAPK—nuclear factor (NF)‐κB—IL8: A possible mechanism of particulate matter (PM) 2.5‐induced lung toxicity

SC Jeong, Y Cho, MK Song, E Lee… - Environmental …, 2017 - Wiley Online Library
Airway inflammation plays a central role in the pathophysiology of diverse pulmonary
diseases. In this study, we investigated whether exposure to particulate matter (PM) 2.5, a …

Exposure to PM2. 5 induces aberrant activation of NF-κB in human airway epithelial cells by downregulating miR-331 expression

L Song, D Li, X Li, L Ma, X Bai, Z Wen, X Zhang… - Environmental …, 2017 - Elsevier
Exposure to particulate matter (PM) with an aerodynamic diameter≤ 2.5 μm (PM2. 5)
induces reactive oxygen species (ROS) and pro-inflammatory cytokine production, leading …

Fine particulate matter induces airway inflammation by disturbing the balance between Th1/Th2 and regulation of GATA3 and Runx3 expression in BALB/c mice

L Pang, P Yu, X Liu, Y Fan… - Molecular medicine …, 2021 - spandidos-publications.com
The present study aimed to examine the effects of 2.5 µm particulate matter (PM2. 5) on
airway inflammation and to investigate the possible underlying mechanism. Specifically, the …

Airborne fine particulate matter induces oxidative stress and inflammation in human nasal epithelial cells

Z Hong, Z Guo, R Zhang, J Xu, W Dong… - The Tohoku journal of …, 2016 - jstage.jst.go.jp
Airborne fine particulate matter with an aerodynamic diameter equal to or smaller than 2.5
μm is abbreviated as PM 2.5, which is one of the main components in air pollution. Exposure …

Endoplasmic reticulum stress mediates environmental particle-induced inflammatory response in bronchial epithelium

L Pu, F Yi, W Yu, Y Li, Y Tu, A Xu… - Journal of …, 2023 - Taylor & Francis
While the detailed mechanisms for how particulate matter (PM) causes adverse health
effects in the lungs remain largely unknown, endoplasmic reticulum (ER) stress has been …

Particulate matter 2.5 triggers airway inflammation and bronchial hyperresponsiveness in mice by activating the SIRT2-p65 pathway

M Liu, Z Shi, Y Yin, Y Wang, N Mu, C Li, H Ma… - Frontiers of …, 2021 - Springer
Abstract Exposure to particulate matter 2.5 (PM2. 5) potentially triggers airway inflammation
by activating nuclear factor-κB (NF-κB). Sirtuin 2 (SIRT2) is a key modulator in inflammation …

Fine particulate matter (PM2. 5) enhances airway hyperresponsiveness (AHR) by inducing necroptosis in BALB/c mice

Y Zhao, H Zhang, X Yang, Y Zhang, S Feng… - Environmental Toxicology …, 2019 - Elsevier
Objective To observe the effects of prolonged exposure to high concentrations of PM 2.5 on
the trachea and lungs of mice and to determine whether the damages to the trachea and …

[HTML][HTML] Fibroblast growth factor 10 protects against particulate matter-induced airway inflammatory response through regulating inflammatory signaling and apoptosis

L Liu, Z Xia, J Li, Y Hu, Q Wang, J Chen… - American journal of …, 2019 - ncbi.nlm.nih.gov
Chronic respiratory disorders are some of the most frequent and severe chronic diseases in
China. Epidemiological research has shown that particulate matter (PM) is a risk factor and …