Synthetic circuits offer great promise for generating insights into nature's underlying design
principles or forward engineering novel biotechnology applications. However, construction …

As genetic circuits become more sophisticated, the size and complexity of data about their
designs increase. The data captured goes beyond genetic sequences alone; information …

The past 20 years have witnessed enormous progress in synthetic biology in the
development of engineered cells for diverse applications, including biomanufacturing …

Synthetic gene circuits are designed to program new biological behaviour, dynamics and
logic control. For all but the simplest synthetic phenotypes, this requires a structured …

Synthetic biology is focused on the rational construction of biological systems based on
engineering principles. During the field's first decade of development, significant progress …

We present a methodology for the design, construction and modification of synthetic gene
networks. This method emphasizes post-assembly modification of constructs based on …

Forward engineering of synthetic genetic circuits in living cells is expected to deliver various
applications in biotechnology and medicine and to provide valuable insights into the design …

Synthetic biology is frequently defined as the application of engineering design principles to
biology. Such principles are intended to streamline the practice of biological engineering, to …

Synthetic genetic circuits are artificial networks of transcriptional control elements inserted
into living cells in order to'program'cellular behavior. We can extend this application to …

Highlights•Synthetic biology aims to apply engineering principles in biology.•Insufficient part
libraries, standards, and software are challenges to the field.•Working on the challenges will …