Complement was initially discovered as an assembly of plasma proteins “complementing”
the cytolytic activity of antibodies. However, our current knowledge places this complex …

Complement is a central part of the immune system that has developed as a first defense
against non-self cells. Neoplastic transformation is accompanied by an increased capacity of …

Complement is an important branch of innate immunity; however, its biological significance
goes far beyond the scope of simple nonspecific defense and involves a variety of …

Simple Summary Increasing evidence supports a role for complement in the development of
cancer and the response to cancer treatments. Dysregulated complement expression within …

Tumor-specific monoclonal antibodies (mAbs) offer several modes of tumor cell killing, from
direct cytotoxic activity to indirect mechanisms employing the host immune system …

The complement system represents a pillar of the innate immune response. This system,
critical for host defense against pathogens, encompasses more than 50 soluble, and …

In tumour immunology, complement has traditionally been considered as an adjunctive
component that enhances the cytolytic effects of antibody-based immunotherapies, such as …

The complement system has traditionally been considered a component of innate immunity
against invading pathogens and “nonself” cells. Recent studies have demonstrated the …

Although it was long believed that the complement system helps the body to identify and
remove transformed cells, it is now clear that complement activation contributes to …

Constituting a part of the innate immune system, the complement system consists of over 50
proteins either acting as part of a 3-branch activation cascade, a well-differentiated …