Background An adverse interaction whereby opioids impair and delay the gastrointestinal
absorption of oral P2Y12 inhibitors has been established, however the clinical significance …

Objectives This study examined if sex differences in prehospital pain scores, opioid
administration, and clinical outcomes exist in acute coronary syndrome (ACS) patients …

Morphine has been long recognized as standard of care in the treatment of acute coronary
syndrome (ACS) patients; however, its safety has recently been called into question due to a …

Objective To characterise the relationship between opioid dose and myocardial infarct size
in patients with ST elevation myocardial infarction (STEMI). Methods Patients given opioid …

Key Points Opioid therapy has served as the cornerstone for pain relief in acute coronary
syndromes (ACS) for several decades. Women with ACS are less likely to receive opioids for …

Analgesics, particularly opioids, have been routinely used in the emergency treatment of
ischemic chest pain for a long time. In the past two decades; however, several studies have …

Opioid analgesics are largely implemented for the relief of acute pain in several clinical
settings, including among patients with acute coronary syndrome (ACS) undergoing …

Background There is increasing evidence that opioids interfere with the oral bioavailability of
P2Y 12 inhibitors leading to delayed onset of antiplatelet effects. Several strategies have …

Alleviation of chest pain in patients with ST-elevation myocardial infarction (STEMI) is vitally
important. Traditionally, opioids are commonly used for this purpose (class IIa in …

Background We explored the impact of chronic opioid use on the clinical outcomes in
patients admitted with acute coronary syndrome (ACS). Methods We identified ACS …