Transcript alterations often result from somatic changes in cancer genomes. Various forms of
RNA alterations have been described in cancer, including overexpression, altered splicing …

Somatic mutations in cancer genomes are caused by multiple mutational processes, each of
which generates a characteristic mutational signature. Here, as part of the Pan-Cancer …

The cancer genome is moulded by the dual processes of somatic mutation and selection.
Homozygous deletions in cancer genomes occur over recessive cancer genes, where they …

Identification of the genes that cause oncogenesis is a central aim of cancer research. We
searched the proteins predicted from the draft human genome sequence for paralogues of …

A key mutational process in cancer is structural variation, in which rearrangements delete,
amplify or reorder genomic segments that range in size from kilobases to whole …

A powerful way to discover key genes with causal roles in oncogenesis is to identify
genomic regions that undergo frequent alteration in human cancers. Here we present high …

Abstract The Cancer Genome Atlas (TCGA) has used the latest sequencing and analysis
methods to identify somatic variants across thousands of tumours. Here we present data and …

Although a few cancer genes are mutated in a high proportion of tumours of a given type (>
20%), most are mutated at intermediate frequencies (2–20%). To explore the feasibility of …

Extensive genomic characterization of human cancers presents the problem of inference
from genomic abnormalities to cancer phenotypes. To address this problem, we analysed …

Lung cancer is the leading cause of cancer-related mortality worldwide, with non-small-cell
lung carcinomas in smokers being the predominant form of the disease,. Although previous …