Cloning a profibrotic stem cell variant in idiopathic pulmonary fibrosis
S Wang, W Rao, A Hoffman, J Lin, J Li, T Lin… - Science translational …, 2023 - science.org
Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible, and rapidly fatal interstitial
lung disease marked by the replacement of lung alveoli with dense fibrotic matrices …
lung disease marked by the replacement of lung alveoli with dense fibrotic matrices …
[PDF][PDF] Two-way conversion between lipogenic and myogenic fibroblastic phenotypes marks the progression and resolution of lung fibrosis
Idiopathic pulmonary fibrosis (IPF) is a form of progressive interstitial lung disease with
unknown etiology. Due to a lack of effective treatment, IPF is associated with a high mortality …
unknown etiology. Due to a lack of effective treatment, IPF is associated with a high mortality …
Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis
We provide a single-cell atlas of idiopathic pulmonary fibrosis (IPF), a fatal interstitial lung
disease, by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 …
disease, by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 …
[HTML][HTML] Identification of a cell-of-origin for fibroblasts comprising the fibrotic reticulum in idiopathic pulmonary fibrosis
H Xia, V Bodempudi, A Benyumov, P Hergert… - The American journal of …, 2014 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive disease of the middle aged and elderly
with a prevalence of one million persons worldwide. The fibrosis spreads from affected …
with a prevalence of one million persons worldwide. The fibrosis spreads from affected …
Origins of pathological myofibroblasts in lung fibrosis: insights from lineage tracing mouse models in the single-cell RNA sequencing era
M Homps-Legrand, B Crestani… - American Journal of …, 2023 - journals.physiology.org
Idiopathic pulmonary fibrosis (IPF) is a rare interstitial lung disease with a poor prognosis.
Chronic microinjuries, mainly caused by environmental factors to an aging alveolar …
Chronic microinjuries, mainly caused by environmental factors to an aging alveolar …
IL-8 mediates idiopathic pulmonary fibrosis mesenchymal progenitor cell fibrogenicity
L Yang, J Herrera, A Gilbertsen, H Xia… - … of Physiology-Lung …, 2018 - journals.physiology.org
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease, but the
mechanisms driving progression remain incompletely defined. We previously reported that …
mechanisms driving progression remain incompletely defined. We previously reported that …
Heterogeneity of fibroblasts and myofibroblasts in pulmonary fibrosis
DM Habiel, CM Hogaboam - Current pathobiology reports, 2017 - Springer
Abstract Purpose of Review Idiopathic pulmonary fibrosis (IPF) is the most common form of
interstitial lung disease of unknown etiopathogenesis with mean survival of 3–5 years and …
interstitial lung disease of unknown etiopathogenesis with mean survival of 3–5 years and …
[HTML][HTML] The quest for the initial lesion in idiopathic pulmonary fibrosis: gene expression differences in IPF fibroblasts
O Eickelberg, GJ Laurent - American journal of respiratory cell and …, 2010 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal disorder due to its unresolved
pathogenesis and limited responsiveness to currently available therapies. It is characterized …
pathogenesis and limited responsiveness to currently available therapies. It is characterized …
Defining the activated fibroblast population in lung fibrosis using single-cell sequencing
R Peyser, S MacDonnell, Y Gao, L Cheng… - American journal of …, 2019 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disorder driven by
unrelenting extracellular matrix deposition. Fibroblasts are recognized as the central …
unrelenting extracellular matrix deposition. Fibroblasts are recognized as the central …
Modeling fibrotic alveolar transitional cells with pluripotent stem cell-derived alveolar organoids
V Ptasinski, SJ Monkley, K Öst, M Tammia… - Life science …, 2023 - life-science-alliance.org
Repeated injury of the lung epithelium is proposed to be the main driver of idiopathic
pulmonary fibrosis (IPF). However, available therapies do not specifically target the …
pulmonary fibrosis (IPF). However, available therapies do not specifically target the …