Alpha lipoic acid ameliorates motor deficits by inhibiting ferroptosis in Parkinson's disease

Q Zheng, P Ma, P Yang, S Zhai, M He, X Zhang, Q Tu… - Neuroscience …, 2023 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disease. Ferroptosis shares several
features with PD pathophysiology, and anti-ferroptosis molecules are neuroprotective in PD …

Benefits of iron chelators in the treatment of Parkinson's disease

X Zeng, H An, F Yu, K Wang, L Zheng, W Zhou… - Neurochemical …, 2021 - Springer
As a novel discovered regulated cell death pattern, ferroptosis has been associated with the
development of Parkinson's disease (PD) and has attracted widespread attention …

α‐Lipoic acid alleviates ferroptosis in the MPP+‐induced PC12 cells via activating the PI3K/Akt/Nrf2 pathway

L Liu, S Yang, H Wang - Cell Biology International, 2021 - Wiley Online Library
Parkinson's disease (PD) is a typical neurodegenerative disease. α‐Lipoic acid (α‐LA) can
reduce the incidence of neuropathy. The present study explored the role and mechanism of …

Alpha-lipoic acid mediates clearance of iron accumulation by regulating iron metabolism in a Parkinson's disease model induced by 6-OHDA

S Tai, Q Zheng, S Zhai, T Cai, L Xu, L Yang… - Frontiers in …, 2020 - frontiersin.org
The disruption of neuronal iron homeostasis and oxidative stress are related to the
pathogenesis of Parkinson's disease (PD). Alpha-lipoic acid (ALA) is a naturally occurring …

Ferroptosis as a new mechanism in Parkinson's disease therapy using traditional Chinese medicine

L Wu, M Liu, J Liang, N Li, D Yang, J Cai… - Frontiers in …, 2021 - frontiersin.org
Parkinson's disease (PD) is one of the most common neurodegenerative diseases. To date,
among medications used to treat PD, only levodopa exhibits a limited disease-modifying …

Ferroptosis was more initial in cell death caused by iron overload and its underlying mechanism in Parkinson's disease

P Zhang, L Chen, Q Zhao, X Du, M Bi, Y Li… - Free Radical Biology …, 2020 - Elsevier
Ferroptosis, an iron-dependent nonapoptotic cell death, was referred in neurodegenerative
diseases, but its role in Parkinson's disease remains unclear. Here, we used ferric …

Apoferritin improves motor deficits in MPTP-treated mice by regulating brain iron metabolism and ferroptosis

LM Song, ZX Xiao, N Zhang, XQ Yu, W Cui, JX Xie… - IScience, 2021 - cell.com
Iron deposition is one of the key factors in the etiology of Parkinson's disease (PD). Iron-free-
apoferritin has the ability to store iron by combining with a ferric hydroxide-phosphate …

N2L, a novel lipoic acid-niacin dimer, attenuates ferroptosis and decreases lipid peroxidation in HT22 cells

W Peng, Z Zhu, Y Yang, J Hou, J Lu, C Chen, F Liu… - Brain Research …, 2021 - Elsevier
Ferroptosis, a new type of programmed cell death discovered in recent years, plays an
important role in many neurodegenerative diseases. N2L is a novel lipoic acid-niacin dimer …

FTH1 inhibits ferroptosis through ferritinophagy in the 6-OHDA model of Parkinson's disease

Y Tian, J Lu, X Hao, H Li, G Zhang, X Liu, X Li, C Zhao… - …, 2020 - Springer
Parkinson's disease (PD) is a neurodegenerative disorder characterized by degeneration of
dopaminergic neurons associated with dysregulation of iron homeostasis in the brain …

Salidroside Mediated the Nrf2/GPX4 Pathway to Attenuates Ferroptosis in Parkinson's Disease

J Shen, S Chen, X Li, L Wu, X Mao, J Jiang… - Neurochemical …, 2024 - Springer
Parkinson's Disease (PD) is characterized by the loss of dopaminergic neurons, with
ferroptosis playing a significant role. Salidroside (SAL) has shown neuroprotective potential …