Background Complement component C5-derived C5a locally generated in the brain has
been shown to protect against glutamate-induced neuronal apoptosis and beta-amyloid (Aβ) …

Human intravenous immunoglobulin (IVIG) has been indicated as a potential therapy for
autoimmune neurological disorders, as well as in many neurodegenerative diseases, with …

Alzheimer's disease (AD) is an age-related dementia, characterized by amyloid plaques,
neurofibrillary tangles, neuroinflammation, and neuronal loss in the brain. Components of …

Complement is dysregulated in the brain in Alzheimer's Disease and in mouse models of
Alzheimer's disease. Each of the complement derived effectors, opsonins, anaphylatoxins …

Background Alzheimer's disease (AD) is the most common neurodegenerative disease
characterized by neuronal loss due to amyloid beta aggregations, neurofibrillary tangles …

In our earlier results, we demonstrated that cells expressing the complement C5aR are
vulnerable since abnormal activation of C5aR caused apoptosis of these cells. In this study …

There is evidence that the complement system, a major component of inflammatory
responses, may play an important role in neurodegenerative conditions such as Alzheimer's …

Background Alzheimer's disease (AD) is a neurodegenerative dementia characterized by
the decline of cognition and the presence of neuropathological changes including neuronal …

According to the amyloid hypothesis of Alzheimer's disease (AD) the deposition of prefibrillar
and fibrillar Aβ peptide sets off the pathogenic cascades of neuroinflammation and …

Objective: The dysregulation of neuro-inflammation is one of the attributes of the
pathogenesis of Alzheimer's disease (AD). Over-expression of complement proteins co …