Cyto-genotoxic and DNA methylation changes induced by different crystal phases of TiO2-np in bronchial epithelial (16-HBE) cells

M Ghosh, D Öner, RC Duca, SM Cokic, S Seys… - Mutation Research …, 2017 - Elsevier
With the increase in use of TiO 2-np, a better understanding of their safety is important. In the
present study the effect of different crystal phases of TiO 2-np (anatase, rutile and anatase …

Epigenetic modulation upon exposure of lung fibroblasts to TiO2 and ZnO nanoparticles: alterations in DNA methylation

NA Patil, WN Gade, DD Deobagkar - International journal of …, 2016 - Taylor & Francis
Titanium dioxide (TiO2) and zinc oxide (ZnO) nanoparticles (NPs) are promising candidates
for numerous applications in consumer products. This will lead to increased human …

Impact of anatase titanium dioxide nanoparticles on mutagenic and genotoxic response in Chinese hamster lung fibroblast cells (V-79): the role of cellular uptake

AK Jain, VA Senapati, D Singh, K Dubey… - Food and chemical …, 2017 - Elsevier
The unique physico-chemical properties of nano crystalline anatase titanium dioxide
nanoparticles (TiO 2 NPs) render them with different biological and chemical activities …

Titanium dioxide nanoparticles induce size-dependent cytotoxicity and genomic DNA hypomethylation in human respiratory cells

Y Ma, Y Guo, S Wu, Z Lv, Q Zhang, Y Ke - RSC advances, 2017 - pubs.rsc.org
The widespread use of titanium dioxide nanoparticles (TiO2 NPs) is gradually increasing the
risk of exposure to these potentially hazardous materials. Although numerous health effects …

Different effects of titanium dioxide nanoparticles instillation in young and adult mice on DNA methylation related with lung inflammation and fibrosis

Y Ma, Y Guo, H Ye, K Huang, Z Lv, Y Ke - Ecotoxicology and Environmental …, 2019 - Elsevier
Wide use of titanium dioxide nanoparticles (TiO 2 NPs) as white pigments induces
unintentionally release in environment which increases concerns about their adverse health …

Multiple endpoints to evaluate pristine and remediated titanium dioxide nanoparticles genotoxicity in lung epithelial A549 cells

A Stoccoro, S Di Bucchianico, F Coppedè, J Ponti… - Toxicology letters, 2017 - Elsevier
Titanium dioxide nanoparticles (TiO 2 NP) are broadly used in a wide range of applications.
Several studies have reported that TiO 2 NP possess cytotoxic and genotoxic properties that …

Effect of titanium dioxide nanoparticles on DNA methylation in multiple human cell lines

M Pogribna, NA Koonce, A Mathew, B Word… - …, 2020 - Taylor & Francis
Nanoscale titanium dioxide (TiO2) is manufactured in wide scale, with a range of
applications in consumer products. Significant toxicity of TiO2 nanoparticles has, however …

Genotoxic effects of nanosized and fine TiO2

GCM Falck, HK Lindberg, S Suhonen… - Human & …, 2009 - journals.sagepub.com
The in-vitro genotoxicity of nanosized TiO2 rutile and anatase was assessed in comparison
with fine TiO2 rutile in human bronchial epithelial BEAS 2B cells using the single-cell gel …

Intracellular distribution, geno-and cytotoxic effects of nanosized titanium dioxide particles in the anatase crystal phase on human nasal mucosa cells

S Hackenberg, G Friehs, K Froelich, C Ginzkey… - Toxicology letters, 2010 - Elsevier
Nanomaterials are defined as substances with at least one dimension smaller than 100nm
in size and are used for a multitude of purposes. Titanium dioxide nanoparticles (TiO2-NPs) …

Shape-engineered titanium dioxide nanoparticles (TiO2-NPs): cytotoxicity and genotoxicity in bronchial epithelial cells

M Gea, S Bonetta, L Iannarelli, AM Giovannozzi… - Food and Chemical …, 2019 - Elsevier
The aim of this study was to evaluate cytotoxicity (WST-1 assay), LDH release (LDH assay)
and genotoxicity (Comet assay) of three engineered TiO 2-NPs with different shapes …