Anti-retroviral therapy (ART) can inhibit HIV proliferation but not achieve virus eradication
from HIV-infected individuals. Under ART-based HIV control, virus-specific CD8+ T-cell …

Despite many efforts to develop AIDS vaccines eliciting virus-specific T-cell responses,
whether induction of these memory T cells by vaccination before human immunodeficiency …

While a diversity of immunogens that elicit qualitatively different cellular immune responses
are being assessed in clinical human immunodeficiency virus vaccine trials, the …

Abstract HIV-specific CD8+ T cells that secrete multiple cytokines in response to Ag
stimulation are associated with the control of virus replication during chronic HIV infection …

CD4+ T cells play a central role in the immunopathogenesis of HIV/AIDS, and their depletion
during chronic HIV infection is a hallmark of disease progression. However, the relative …

ABSTRACT A major barrier to human immunodeficiency virus (HIV) eradication is the long-
term persistence of latently infected CD4+ T cells harboring integrated replication-competent …

ABSTRACT Adaptive CD4+ and CD8+ T-cell responses have been associated with control
of human immunodeficiency virus/simian immunodeficiency virus (HIV/SIV) replication …

Our limited understanding of the interaction between primate lentiviruses and the host
immune system complicates the design of an effective HIV/AIDS vaccine. To identify …

Infection with HIV persists despite suppressive antiretroviral therapy (ART), and treatment
interruption results in rapid viral rebound. Antibody-mediated CD8+ lymphocyte depletion in …

Background A vaccine for HIV-1 would ideally block HIV-1 acquisition as well as durably
control viral replication in breakthrough infections. A recently published study showed that …