Regulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPK
A Kucharska, LK Rushworth, C Staples, NA Morrice… - Cellular signalling, 2009 - Elsevier
DUSP5 is an inducible, nuclear, dual-specificity phosphatase, which specifically interacts
with and inactivates the ERK1/2 MAP kinases in mammalian cells. In addition, expression of …
with and inactivates the ERK1/2 MAP kinases in mammalian cells. In addition, expression of …
Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5
M Mandl, DN Slack, SM Keyse - Molecular and cellular biology, 2005 - Taylor & Francis
The mechanisms which determine the nuclear accumulation and inactivation of the
extracellular signal-regulated kinase 1 (ERK1) or ERK2 mitogen-activated protein (MAP) …
extracellular signal-regulated kinase 1 (ERK1) or ERK2 mitogen-activated protein (MAP) …
Post‐transcriptional regulation of the DUSP6/MKP‐3 phosphatase by MEK/ERK signaling and hypoxia
O Bermudez, P Jouandin, J Rottier… - Journal of cellular …, 2011 - Wiley Online Library
Abstract DUSP6/MKP‐3 is a cytoplasmic dual‐specificity phosphatase specific for the MAP
kinases ERK1/2. Previous data have shown that the MEK/ERK axis exerts a retro‐control on …
kinases ERK1/2. Previous data have shown that the MEK/ERK axis exerts a retro‐control on …
Dual-specificity phosphatase DUSP6 has tumor-promoting properties in human glioblastomas
Abstract Dual-specificity phosphatase 6 (DUSP6, mitogen-activated protein kinase (MAPK)
phosphatase 3 or PYST1) dephosphorylates phosphotyrosine and phosphothreonine …
phosphatase 3 or PYST1) dephosphorylates phosphotyrosine and phosphothreonine …
Dual specificity phosphatase 5, a specific negative regulator of ERK signaling, is induced by serum response factor and Elk-1 transcription factor
C Buffet, MG Catelli, K Hecale-Perlemoine, L Bricaire… - PloS one, 2015 - journals.plos.org
Serum stimulation of mammalian cells induces, via the MAPK pathway, the nuclear protein
DUSP5 (dual-specificity phosphatase 5), which specifically interacts with and inactivates the …
DUSP5 (dual-specificity phosphatase 5), which specifically interacts with and inactivates the …
Post-translational regulation of the ERK phosphatase DUSP6/MKP3 by the mTOR pathway
O Bermudez, S Marchetti, C Gimond - Oncogene, 2008 - nature.com
MAP kinases phosphatases (MKPs) belong to the dual-specificity phosphatase family
(DUSP) and dephosphorylate phosphothreonine and phosphotyrosine within MAP kinases …
(DUSP) and dephosphorylate phosphothreonine and phosphotyrosine within MAP kinases …
DUSP6/MKP-3 inactivates ERK1/2 but fails to bind and inactivate ERK5
RS Arkell, RJ Dickinson, M Squires, S Hayat… - Cellular signalling, 2008 - Elsevier
Extracellular signal-regulated kinase-1 and-2 (ERK1/2) are activated by dual threonine and
tyrosine phosphorylation of a TEY motif. The highly related kinase ERK5 is also activated by …
tyrosine phosphorylation of a TEY motif. The highly related kinase ERK5 is also activated by …
Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2
M Perander, R Al-Mahdi, TC Jensen, JAL Nunn… - Scientific reports, 2017 - nature.com
The atypical MAP kinases ERK3 and ERK4 are activated by phosphorylation of a serine
residue lying within the activation loop signature sequence SEG. However, the regulation of …
residue lying within the activation loop signature sequence SEG. However, the regulation of …
Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling
AM Kidger, LK Rushworth, J Stellzig… - Proceedings of the …, 2017 - National Acad Sciences
Deregulated extracellular signal-regulated kinase (ERK) signaling drives cancer growth.
Normally, ERK activity is self-limiting by the rapid inactivation of upstream kinases and …
Normally, ERK activity is self-limiting by the rapid inactivation of upstream kinases and …
Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its …
S Marchetti, C Gimond, JC Chambard… - … and cellular biology, 2005 - Taylor & Francis
Mitogen-activated protein (MAP) kinase phosphatases (MKPs) are dual-specificity
phosphatases that dephosphorylate phosphothreonine and phosphotyrosine residues …
phosphatases that dephosphorylate phosphothreonine and phosphotyrosine residues …