Cartilage and the bordering subchondral bone form a functionally active regulatory interface
with a prominent role in osteoarthritis pathways. The Wnt and the OPG-RANKL-RANK …

Wnt signalling pathways have key roles in joint development, homeostasis and disease,
particularly in osteoarthritis. New data is starting to reveal the importance of tightly regulating …

Osteochondral junction is a functional unit comprising the articular cartilage, calcified
cartilage, and subchondral bone. Alteration in any component of this composite unit can …

Context: Osteoarthritis (OA) is an articular disorder leading to the degradation of articular
cartilage phenotypical chondrocytes modifications, including the acquisition of a fibroblast …

Osteoarthritis is a common disease, clinically manifested by joint pain, swelling and
progressive loss of function. The severity of disease manifestations can vary but most of the …

The Wnt signalling cascades have essential roles in development, growth and homeostasis
of joints and the skeleton. Progress in basic research, particularly relating to our …

Cartilage not only plays essential roles in skeletal development and growth during pre-and
postnatal stages but also serves to provide smooth movement of skeletons throughout life …

Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

Rheumatoid arthritis (RA) is a chronic, debilitating autoimmune disease that results in
inflammation and structural destruction of the joints. A hallmark of RA pathogenesis is an …

The cartilage damage which characterizes osteoarthritis is often accompanied by bone
lesions. Joint integrity results from the balance in the physiological interactions between …