Cytochrome P450 epoxygenases as EDHF synthase (s)
I Fleming - Pharmacological research, 2004 - Elsevier
The metabolism of arachidonic acid by cytochrome P450 (CYP) epoxygenases generates
epoxyeicosatrienoic acids (EETs) which affect numerous cellular process including Ca2+ …
epoxyeicosatrienoic acids (EETs) which affect numerous cellular process including Ca2+ …
The factor in EDHF: Cytochrome P450 derived lipid mediators and vascular signaling
I Fleming - Vascular pharmacology, 2016 - Elsevier
Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to generate
epoxyeicosatrienoic acids (EETs). The latter are biologically active and reported to act as an …
epoxyeicosatrienoic acids (EETs). The latter are biologically active and reported to act as an …
Endothelium-derived epoxyeicosatrienoic acids and vascular function
I Fleming, R Busse - Hypertension, 2006 - Am Heart Assoc
Epoxyeicosatrienoic acids (EETs) are epoxides of arachidonic acid generated by
cytochrome P450 (CYP) epoxygenases. The activation of CYP epoxygenases in endothelial …
cytochrome P450 (CYP) epoxygenases. The activation of CYP epoxygenases in endothelial …
Origin and function of epoxyeicosatrienoic acids in vascular endothelial cells: more than just endothelium‐derived hyperpolarizing factor?
BG Hoebel, E Steyrer, WF Graier - Clinical and experimental …, 1998 - Wiley Online Library
In addition to their contribution to endothelium‐derived hyperpolarization, our understanding
of the physiological function of epoxyeicosatrienoic acids (EET) within the vascular wall and …
of the physiological function of epoxyeicosatrienoic acids (EET) within the vascular wall and …
Epoxygenase metabolites: epithelial and vascular actions
JD Imig - Molecular biotechnology, 2000 - Springer
Abstract Cytochrome P450 (CYP450) epoxygenase enzymes demonstrate organ and cell
specific expression and each CYP450 enzyme isoform produces a distinct pattern of …
specific expression and each CYP450 enzyme isoform produces a distinct pattern of …
From endothelium-derived hyperpolarizing factor (EDHF) to angiogenesis: Epoxyeicosatrienoic acids (EETs) and cell signaling
UR Michaelis, I Fleming - Pharmacology & therapeutics, 2006 - Elsevier
Epoxyeicosatrienoic acids (EETs) are generated from arachidonic acid by cytochrome P450
(CYP) epoxygenases. The expression of CYP epoxygenases in endothelial cells is …
(CYP) epoxygenases. The expression of CYP epoxygenases in endothelial cells is …
Epoxyeicosatrienoic acids and 20-hydroxyeicosatetraenoic acid on endothelial and vascular function
JD Imig - Advances in pharmacology, 2016 - Elsevier
Endothelial and vascular smooth cells generate cytochrome P450 (CYP) arachidonic acid
metabolites that can impact endothelial cell function and vascular homeostasis. The …
metabolites that can impact endothelial cell function and vascular homeostasis. The …
Hydrogen peroxide inhibits cytochrome p450 epoxygenases: interaction between two endothelium-derived hyperpolarizing factors
BT Larsen, DD Gutterman, A Sato, K Toyama… - Circulation …, 2008 - Am Heart Assoc
The cytochrome P450 epoxygenase (CYP)-derived metabolites of arachidonic acid the
epoxyeicosatrienoic acids (EETs) and hydrogen peroxide (H2O2) both function as …
epoxyeicosatrienoic acids (EETs) and hydrogen peroxide (H2O2) both function as …
Epoxyeicosatrienoic acids, cell signaling and angiogenesis
I Fleming - Prostaglandins & other lipid mediators, 2007 - Elsevier
Epoxyeicosatrienoic acids (EETs) are generated from arachidonic acid by cytochrome P450
(CYP) epoxygenases the expression of which is determined by hemodynamic and …
(CYP) epoxygenases the expression of which is determined by hemodynamic and …
Pathways of epoxyeicosatrienoic acid metabolism in endothelial cells: implications for the vascular effects of soluble epoxide hydrolase inhibition
X Fang, TL Kaduce, NL Weintraub, S Harmon… - Journal of Biological …, 2001 - ASBMB
Epoxyeicosatrienoic acids (EETs) are products of cytochrome P-450 epoxygenase that
possess important vasodilating and anti-inflammatory properties. EETs are converted to the …
possess important vasodilating and anti-inflammatory properties. EETs are converted to the …