Novel antimalarial drug targets: hope for new antimalarial drugs
Malaria is a major global threat, that results in more than 2 million deaths each year. The
treatment of malaria is becoming extremely difficult due to the emergence of drug-resistant …
treatment of malaria is becoming extremely difficult due to the emergence of drug-resistant …
A glimpse into the clinical proteome of human malaria parasites Plasmodium falciparum and Plasmodium vivax
Malaria causes a worldwide annual mortality of about a million people. Rapidly evolving
drug‐resistant species of the parasite have created a pressing need for the identification of …
drug‐resistant species of the parasite have created a pressing need for the identification of …
Drug Targets for Plasmodium falciparum: a post-genomic review/survey.
Over 300 million cases of malaria each year cause significant morbidity and mortality.
Growing drug-resistance among the Plasmodia that cause malaria motivates the …
Growing drug-resistance among the Plasmodia that cause malaria motivates the …
Multi‐targeted activity of maslinic acid as an antimalarial natural compound
Most drugs against malaria that are available or under development target a single process
of the parasite infective cycle, favouring the appearance of resistant mutants which are …
of the parasite infective cycle, favouring the appearance of resistant mutants which are …
Metabolome modulation of the host adaptive immunity in human malaria
W Abdrabou, MM Dieng, A Diawara, SS Sermé… - Nature …, 2021 - nature.com
Host responses to infection with the malaria parasite Plasmodium falciparum vary among
individuals for reasons that are poorly understood. Here we reveal metabolic perturbations …
individuals for reasons that are poorly understood. Here we reveal metabolic perturbations …
New molecular targets and strategies for antimalarial discovery
AC Aguiar, LRF de Sousa, CRS Garcia… - Current Medicinal …, 2019 - ingentaconnect.com
Malaria remains a major health problem, especially because of the emergence of resistant
P. falciparum strains to artemisinin derivatives. In this context, safe and affordable …
P. falciparum strains to artemisinin derivatives. In this context, safe and affordable …
Malaria pathogenesis: a jigsaw with an increasing number of pieces
A Heddini - International journal for parasitology, 2002 - Elsevier
Plasmodiumfalciparum malaria remains as one of the most devastating global health
problems of today. It is estimated that around 150 million individuals get the disease every …
problems of today. It is estimated that around 150 million individuals get the disease every …
Targeted phenotypic screening in Plasmodium falciparum and Toxoplasma gondii reveals novel modes of action of medicines for malaria venture malaria box …
G Subramanian, MA Belekar, A Shukla, JX Tong… - Msphere, 2018 - Am Soc Microbiol
ABSTRACT The Malaria Box collection includes 400 chemically diverse small molecules
with documented potency against malaria parasite growth, but the underlying modes of …
with documented potency against malaria parasite growth, but the underlying modes of …
Malaria proteomics: insights into the parasite–host interactions in the pathogenic space
JM Bautista, P Marín-García, A Diez, IG Azcárate… - Journal of …, 2014 - Elsevier
Proteomics is improving malaria research by providing global information on relevant
protein sets from the parasite and the host in connection with its cellular structures and …
protein sets from the parasite and the host in connection with its cellular structures and …
Metabolomics-based screening of the malaria box reveals both novel and established mechanisms of action
DJ Creek, HH Chua, SA Cobbold… - Antimicrobial agents …, 2016 - Am Soc Microbiol
High-throughput phenotypic screening of chemical libraries has resulted in the identification
of thousands of compounds with potent antimalarial activity, although in most cases, the …
of thousands of compounds with potent antimalarial activity, although in most cases, the …