Novel antimalarial drug targets: hope for new antimalarial drugs

A Alam, M Goyal, MS Iqbal, C Pal, S Dey… - Expert Review of …, 2009 - Taylor & Francis
Malaria is a major global threat, that results in more than 2 million deaths each year. The
treatment of malaria is becoming extremely difficult due to the emergence of drug-resistant …

A glimpse into the clinical proteome of human malaria parasites Plasmodium falciparum and Plasmodium vivax

P Acharya, R Pallavi, S Chandran… - PROTEOMICS …, 2009 - Wiley Online Library
Malaria causes a worldwide annual mortality of about a million people. Rapidly evolving
drug‐resistant species of the parasite have created a pressing need for the identification of …

Drug Targets for Plasmodium falciparum: a post-genomic review/survey.

I Yeh, RB Altman - Mini Reviews in Medicinal Chemistry, 2006 - europepmc.org
Over 300 million cases of malaria each year cause significant morbidity and mortality.
Growing drug-resistance among the Plasmodia that cause malaria motivates the …

Multi‐targeted activity of maslinic acid as an antimalarial natural compound

C Moneriz, J Mestres, JM Bautista, A Diez… - The FEBS …, 2011 - Wiley Online Library
Most drugs against malaria that are available or under development target a single process
of the parasite infective cycle, favouring the appearance of resistant mutants which are …

Metabolome modulation of the host adaptive immunity in human malaria

W Abdrabou, MM Dieng, A Diawara, SS Sermé… - Nature …, 2021 - nature.com
Host responses to infection with the malaria parasite Plasmodium falciparum vary among
individuals for reasons that are poorly understood. Here we reveal metabolic perturbations …

New molecular targets and strategies for antimalarial discovery

AC Aguiar, LRF de Sousa, CRS Garcia… - Current Medicinal …, 2019 - ingentaconnect.com
Malaria remains a major health problem, especially because of the emergence of resistant
P. falciparum strains to artemisinin derivatives. In this context, safe and affordable …

Malaria pathogenesis: a jigsaw with an increasing number of pieces

A Heddini - International journal for parasitology, 2002 - Elsevier
Plasmodiumfalciparum malaria remains as one of the most devastating global health
problems of today. It is estimated that around 150 million individuals get the disease every …

Targeted phenotypic screening in Plasmodium falciparum and Toxoplasma gondii reveals novel modes of action of medicines for malaria venture malaria box …

G Subramanian, MA Belekar, A Shukla, JX Tong… - Msphere, 2018 - Am Soc Microbiol
ABSTRACT The Malaria Box collection includes 400 chemically diverse small molecules
with documented potency against malaria parasite growth, but the underlying modes of …

Malaria proteomics: insights into the parasite–host interactions in the pathogenic space

JM Bautista, P Marín-García, A Diez, IG Azcárate… - Journal of …, 2014 - Elsevier
Proteomics is improving malaria research by providing global information on relevant
protein sets from the parasite and the host in connection with its cellular structures and …

Metabolomics-based screening of the malaria box reveals both novel and established mechanisms of action

DJ Creek, HH Chua, SA Cobbold… - Antimicrobial agents …, 2016 - Am Soc Microbiol
High-throughput phenotypic screening of chemical libraries has resulted in the identification
of thousands of compounds with potent antimalarial activity, although in most cases, the …